Upcoming Events

Edinburgh SPM Course 2019 Apr 01, 2019 - Apr 05, 2019 — University of Edinburgh
Health Innovation and Technologies Research Festival Apr 01, 2019 - Apr 02, 2019 — James Watt Centre, Heriot-Watt University, Edinburgh
PET3D training workshop on integrating PET imaging in drug development Apr 04, 2019 09:00 AM - 05:00 PM — Vrije Universiteit Brussel, Brussels, Belgium
RiiSE19 Conference Apr 13, 2019 09:00 AM - 04:45 PM — Chancellor's Building, Edinburgh, EH16 4SB
Scottish Dementia Research Consortium Annual Conference 2019 Apr 15, 2019 10:00 AM - 04:00 PM — Radisson Blu, 301 Argyle St, Glasgow

SINAPSE Image of the Month: Retinal vascular parameters

May 2018 SINAPSE Image of the Month

Courtesy of Dr Tom MacGillivray, this image of the retina was acquired with an ultra-widefield (UWF) scanning laser ophthalmoscope (Optos P200C AF). UWF technology allows the entire retina to be imaged, including the periphery. Software developed by SINAPSE researchers in the Vascular Assessment and Measurement Platform for Images of the REtina (VAMPIRE) project measures the following retinal vascular parameters for grading: the complexity of the vascular branching pattern [turquoise lines], branching points [green dots], and vessel widths for arterioles [red line] and venules [blue line]. Such vascular characteristics quantifiable on retinal imaging have been shown to reflect cerebrovascular health, complementing brain imaging.

A recently published pilot study in collaboration with VAMPIRE and researchers at Queen's University Belfast identified retinal vascular parameters analysed from UWF images as potential biomarkers for Alzheimer’s disease and its progression:

Csincsik L, MacGillivray TJ, Flynn E, Pellegrini  E, Papanastasiou G, Barzegar-Befroei N, Csutak A, Bird AC, Ritchie CW, Peto T, Lengyel I. Peripheral Retinal Imaging Biomarkers for Alzheimer’s Disease: A Pilot Study. Ophthalmic Res 2018; 59:182-192.