Upcoming Events

ISMRM Workshop on MR Value Mar 11, 2019 - Mar 13, 2019 — University of Edinburgh
European Molecular Imaging Meeting 2019 Mar 19, 2019 - Mar 22, 2019 — Scottish Event Campus, Glasgow
2nd International Conference on Medical Imaging with Deep Learning Jul 08, 2019 - Jul 10, 2019 — ICL South Kensington Campus, London
4th International Workshop on Image Processing Techniques and Applications Jul 22, 2019 - Jul 23, 2019 — Centre for Mathematical Imaging Techniques (CMIT), University of Liverpool, England
Medical Image Understanding and Analysis Conference 2019 Jul 24, 2019 - Jul 26, 2019 — University of Liverpool, England

SINAPSE Image of the Month: MR spectroscopy of brain white matter

August 2018 SINAPSE Image of the Month

Courtesy of Prof Ian Marshall, this image shows a magnetic resonance spectroscopic imaging (MRSI) slice for measuring brain metabolites in an individual with secondary progressive multiple sclerosis. The spectroscopic excitation volume is shown with a red outline, and tissue segmentation is illustrated with coloured shading: green indicates normal-appearing white matter and pale blue indicates white matter lesions (WML) which are characteristic of multiple sclerosis.

MRSI estimates metabolite concentrations in voxels within the brain, and can be used to investigate differences in metabolite levels between tissue types within individuals. In a group of patients with secondary progressive multiple sclerosis, MRSI showed higher levels of choline, creatine and myo-inositol in WML relative to normal-appearing white matter. These differences are indicative of higher myelin turnover, higher metabolic rate and increased glial activity in WML, suggesting that the lesions have ongoing abnormal metabolism, which may represent a target for repair therapies.

 

The image is taken from a recent study published in Journal of Neurology:

Marshall I, Thrippleton MJ, Bastin ME, Mollison D, Dickie DA, Chappell FM, Semple SIK, Cooper A, Pavitt S, Giovannoni G, Wheeler-Kingshott CAMG, Solanky BS, Weir CJ, Stallard N, Hawkins C, Sharrack B, Chataway J, Connick P, Chandran S; for the MS-SMART Trialists. Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis: a magnetic resonance spectroscopic imaging study. J Neurol 2018; 265:1795-1802.