Upcoming Events

Edinburgh SPM Course 2019 Apr 01, 2019 - Apr 05, 2019 — University of Edinburgh
Health Innovation and Technologies Research Festival Apr 01, 2019 - Apr 02, 2019 — James Watt Centre, Heriot-Watt University, Edinburgh
PET3D training workshop on integrating PET imaging in drug development Apr 04, 2019 09:00 AM - 05:00 PM — Vrije Universiteit Brussel, Brussels, Belgium
RiiSE19 Conference Apr 13, 2019 09:00 AM - 04:45 PM — Chancellor's Building, Edinburgh, EH16 4SB
Scottish Dementia Research Consortium Annual Conference 2019 Apr 15, 2019 10:00 AM - 04:00 PM — Radisson Blu, 301 Argyle St, Glasgow

SINAPSE Image of the Month: TSPO PET Radiotracer

April 2018 SINAPSE Image of the Month

Courtesy of Dr Adriana Tavares, this image shows PET signal measured in heart using a new radiotracer for imaging cardiovascular inflammation. Targeting the 18 kDa translocator protein (TSPO), this is the first fluorinated TSPO PET radiotracer with binding to human tissue independent from the rs6971 genetic polymorphism.

This collaborative work (Universities of Edinburgh and Glasgow) is currently at the radiotracer preclinical validation stage with aim of translating to humans, and has recently received funding support from the British Heart Foundation.

An important property of the new TSPO PET radiotracer is its selectivity for imaging inflammation, as shown below: the signal measured in heart is reduced from before (left) to after (right) administration of PK11195, a selective TSPO drug.