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PET is Wonderful & NHS Lothian International Meeting Feb 19, 2018 02:00 PM - 05:00 PM — Wellcome Auditorium/Fyfe Rooms, Queen’s Medical Research Institute, University of Edinburgh
'Let's Talk About Health' free public lecture Feb 21, 2018 05:30 PM - 06:30 PM — Wellcome Auditorium, Queen’s Medical Research Institute, University of Edinburgh
Edinburgh CVS-Neuroscience network launch Feb 22, 2018 01:00 PM - 05:00 PM — Wellcome Auditorium, Queen’s Medical Research Institute, University of Edinburgh
Intelligent Imaging KTN event Mar 15, 2018 09:30 AM - 05:00 PM — The Lighthouse, 56 Mitchell Street, Glasgow
Scottish Dementia Research Consortium Annual Conference 2018 Apr 23, 2018 10:00 AM - 04:00 PM — Radisson Blu, 301 Argyle St, Glasgow

SINAPSE Image of the Month: DTI visualisation

June 2017 SINAPSE Image of the Month

Courtesy of Shaun Stone, this image demonstrates the MR-based neuroimaging technique of diffusion tensor imaging (DTI), which allows estimation of microstructural integrity, location, orientation and anisotropy of the brain’s white matter tracts. Fractional anisotropy (FA) is a measure of anisotropic diffusion of water molecules within the white matter fibres of the brain, and FA maps for the visualisation above were generated using diffusion-weighted images taken by a 3T MRI scanner at the University of Aberdeen.

Eigenvectors (ε1, ε2, ε3) give the directions of water diffusion, and the corresponding eigenvalues (λ1, λ2, λ3) give the magnitude of the diffusion process in each direction. The top row of images shows the principal eigenvector modulated to the FA map as an RGB colour map, while the bottom row of images show the principal eigenvector displayed as Lines RGB. The three colours correspond to the principal diffusion direction, with proportional intensity according to the FA value. Red lines = left/right. Blue lines = superior/inferior. Green lines = anterior/posterior.

Images shown were obtained from a 61-year-old healthy male who was originally part of the Aberdeen Children of the Nineteen Fifties (ACONF) cohort, who returned for late-life brain imaging as part of the Stratifying Resilience and Depression Longitudinally (STRADL) project.

Shaun’s research, under the guidance of Prof Alison Murray and Dr Gordon Waiter, aims to develop prediction models of cognitive reserve using a machine learning approach. This project is part funded by SINAPSE and industry partners, IXICO PLC.