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Scottish Ultrasound Pre-IUS meeting Sep 27, 2019 02:00 PM - 05:00 PM — University of Strathclyde
LARIF Workshop: Large animal models and imaging in biomedical research Oct 01, 2019 09:30 AM - 04:30 PM — Roslin Institute Auditorium, Easter Bush Campus, University of Edinburgh
Radiology events and learning from discrepancies Oct 04, 2019 09:00 AM - 05:00 PM — 200 St Vincent Street, Glasgow
IEEE International Ultrasonics Symposium 2019 Oct 06, 2019 - Oct 09, 2019 — Scottish Events Campus, Glasgow
Predictive Intelligence in Medicine MICCAI 2019 Workshop Oct 13, 2019 12:00 AM — Shenzhen, China

SINAPSE Image of the Month: Manganese-enhanced MRI

September 2019 SINAPSE Image of the Month

Courtesy of Dr Scott Semple, this image shows cardiac MRI tissue characterisation in a patient with myocardial infarction, comparing native T1 mapping at left (A) with manganese-enhanced MRI (MEMRI) T1 mapping at right (B). Shortened T1 in remote myocardium is evident on MEMRI, discriminable from infarcted myocardium.

Manganese-based contrast agents in MRI reduce the T1 relaxation time of water, enabling contrast in tissues where it accumulates (such as the myocardium). As a calcium analogue, manganese is taken up avidly by voltage-gated calcium channels into cells with active calcium handling, therefore its uptake is absent in infarcted tissue. With its ability to label viable myocardium directly, and the natural occurrence of manganese in vivo making its safety and toxicity profile more attractive than gadolinium, MEMRI offers exciting potential for myocardial viability assessment and wider clinical translation.

 

The image is taken from a recent review published in Heart:

Spath NB, Thompson G, Baker AH, Dweck MR, Newby DE, Semple SIK. Manganese-enhanced MRI of the myocardium. Heart 2019; Epub ahead of print.