Upcoming Events

Neuroimaging in diseases that cause dementia Aug 22, 2019 - Aug 23, 2019 — King’s College Conference Centre, University of Aberdeen
2019 UK PET Chemistry Meeting Sep 09, 2019 09:00 AM - 05:45 PM — Michael Smith Building, University of Manchester
Total Body PET Workshop Sep 12, 2019 - Sep 13, 2019 — Belgian Centre for Comic Strip Art, Brussels, Belgium
Radiology events and learning from discrepancies Oct 04, 2019 09:00 AM - 05:00 PM — 200 St Vincent Street, Glasgow
IEEE International Ultrasonics Symposium 2019 Oct 06, 2019 - Oct 09, 2019 — Scottish Events Campus, Glasgow

SINAPSE Image of the Month: Optical endomicroscopy

November 2018 SINAPSE Image of the Month

Courtesy of Dr Ahsan Akram, this image demonstrates molecular imaging of bacteria in human lungs using fluorescent probes and optical endomicroscopy, tiny fibre-optic tubes that obtain images from deep inside lung airways. This new imaging technology developed in the EPSRC-funded Proteus project has been shown to be safe and practical for rapidly detecting bacteria in patients with lung infections.

In a patient suspected to have the chronic lung infection bronchiectasis, baseline optical endomicroscopy imaging of the alveoli (tiny air sacs inside the lungs) is shown at left; imaging after administration of a fluorescent probe to label Gram-negative bacteria is shown at centre. Image analysis to detect labeled bacteria is shown at right, utilised by an algorithm to distinguish Gram-negative from Gram-positive bacterial infections.

 

The image is taken from a recent study published in Science Translational Medicine:

Akram AR, Chankeshwara SV, Scholefield E, Aslam T, McDonald N, Megia-Fernandez A, Marshall A, Mills B, Avlonitis N, Craven TH, Smyth AM, Collie DS, Gray C, Hirani N, Hill AT, Govan JR, Walsh T, Haslett C, Bradley M, Dhaliwal K. In situ identification of Gram-negative bacteria in human lungs using a topical fluorescent peptide targeting lipid A. Sci Transl Med 2018; 10(464):eaal0033.