Upcoming Events

Neuroimaging in diseases that cause dementia Aug 22, 2019 - Aug 23, 2019 — King’s College Conference Centre, University of Aberdeen
2019 UK PET Chemistry Meeting Sep 09, 2019 09:00 AM - 05:45 PM — Michael Smith Building, University of Manchester
Total Body PET Workshop Sep 12, 2019 - Sep 13, 2019 — Belgian Centre for Comic Strip Art, Brussels, Belgium
Radiology events and learning from discrepancies Oct 04, 2019 09:00 AM - 05:00 PM — 200 St Vincent Street, Glasgow
IEEE International Ultrasonics Symposium 2019 Oct 06, 2019 - Oct 09, 2019 — Scottish Events Campus, Glasgow

SINAPSE Image of the Month: TSPO PET Radiotracer

April 2018 SINAPSE Image of the Month

Courtesy of Dr Adriana Tavares, this image shows PET signal measured in heart using a new radiotracer for imaging cardiovascular inflammation. Targeting the 18 kDa translocator protein (TSPO), this is the first fluorinated TSPO PET radiotracer with binding to human tissue independent from the rs6971 genetic polymorphism.

This collaborative work (Universities of Edinburgh and Glasgow) is currently at the radiotracer preclinical validation stage with aim of translating to humans, and has recently received funding support from the British Heart Foundation.

An important property of the new TSPO PET radiotracer is its selectivity for imaging inflammation, as shown below: the signal measured in heart is reduced from before (left) to after (right) administration of PK11195, a selective TSPO drug.