Upcoming Events

The transformative potential of data and image analysis for eye care Apr 23, 2018 - Apr 24, 2018 — The Royal Society, Carlton House Terrace, London
Scottish Dementia Research Consortium Annual Conference 2018 Apr 23, 2018 10:00 AM - 04:00 PM — Radisson Blu, 301 Argyle St, Glasgow
British Cardiovascular Imaging 2018 May 02, 2018 - May 04, 2018 — John McIntyre Conference Centre, Edinburgh
2nd SINAPSE Psychology meeting May 08, 2018 10:30 AM - 04:00 PM — Yudowitz Seminar Room, Wolfson Medical Building, University of Glasgow
2nd PET is Wonderful International Meeting May 14, 2018 02:00 PM - 05:00 PM — Wellcome Auditorium/Fyfe Rooms, Queen’s Medical Research Institute, University of Edinburgh

SINAPSE Image of the Month: TSPO PET Radiotracer

April 2018 SINAPSE Image of the Month

Courtesy of Dr Adriana Tavares, this image shows PET signal measured in heart using a new radiotracer for imaging cardiovascular inflammation. Targeting the 18 kDa translocator protein (TSPO), this is the first fluorinated TSPO PET radiotracer with binding to human tissue independent from the rs6971 genetic polymorphism.

This collaborative work (Universities of Edinburgh and Glasgow) is currently at the radiotracer preclinical validation stage with aim of translating to humans, and has recently received funding support from the British Heart Foundation.

An important property of the new TSPO PET radiotracer is its selectivity for imaging inflammation, as shown below: the signal measured in heart is reduced from before (left) to after (right) administration of PK11195, a selective TSPO drug.