Upcoming Events

Digital Health Product Forge Feb 21, 2019 - Feb 24, 2019 — The Crags Centre, 10 Bowmont Place, Edinburgh
Professor James Boardman inaugural lecture Feb 25, 2019 05:30 PM - 06:30 PM — Lecture Theatre A, Chancellor's Building, Edinburgh, EH16 4SB
ISMRM Workshop on MR Value Mar 11, 2019 - Mar 13, 2019 — University of Edinburgh
Scotland's New Industrial Centre for AI Research in Digital Diagnostics: Vision & Opportunities in Grampian Mar 11, 2019 06:00 PM - 08:00 PM — The Rowett Institute, Ashgrove Road West, Aberdeen
Scotlands New Industrial Centre for AI Research in Digital Diagnostics: Vision & Opportunities in Glasgow Mar 14, 2019 11:30 AM - 01:30 PM — Teaching and Learning Centre, Queen Elizabeth University Hospital Glasgow

SINAPSE Image of the Month: TSPO PET Radiotracer

April 2018 SINAPSE Image of the Month

Courtesy of Dr Adriana Tavares, this image shows PET signal measured in heart using a new radiotracer for imaging cardiovascular inflammation. Targeting the 18 kDa translocator protein (TSPO), this is the first fluorinated TSPO PET radiotracer with binding to human tissue independent from the rs6971 genetic polymorphism.

This collaborative work (Universities of Edinburgh and Glasgow) is currently at the radiotracer preclinical validation stage with aim of translating to humans, and has recently received funding support from the British Heart Foundation.

An important property of the new TSPO PET radiotracer is its selectivity for imaging inflammation, as shown below: the signal measured in heart is reduced from before (left) to after (right) administration of PK11195, a selective TSPO drug.