Medical Imaging Convention [rescheduled] Sep 15, 2021 - Sep 16, 2021 — National Exhibition Centre, Birmingham, England
2021 SINAPSE ASM Sep 16, 2021 - Sep 17, 2021 — Technology & Innovation Centre, University of Strathclyde, 99 George Street, Glasgow
Total Body PET 2021 conference [rescheduled] Sep 22, 2021 - Sep 24, 2021 — Virtual Meeting (online)
PET is Wonderful Annual Meeting 2021 Oct 26, 2021 12:00 AM — Virtual Meeting (online)

eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Mr Abdul Mumuni

Position: SINAPSE PhD Student
Institute: Institute of Neurological Sciences
Department: Imaging Physics/Psychological Medicine


Description of Phd:

 

Proton magnetic resonance spectroscopy (1H MRS) measures brain metabolites noninvasively in vivo. The current literature on 1H MRS studies in Major Depressive Disorder (MDD) is small and heterogeneous. Nevertheless, there is strong evidence that changes in neurometabolite concentrations in MDD occur within brain regions that can be monitored by 1H MRS (1-4). Treatment-resistant depression (TRD) is a common but poorly understood condition. Recent MRS data has reported neuronal damage, loss and metabolic abnormalities in some brain areas, thus may provide an important measurement tool in TRD. Unfortunately the brain areas of primary interest are the thalamus, hippocampus and anterior cingulate which are both small and irregularly shaped. This makes the positioning of the volumes of interest (VOIs) in MRS difficult. Firstly the VOIs are large (typically at least 1cm3 even at 3T) which means that spectra are often contaminated by signal originating from outside the area of interest. Secondly the edges of the voxels are straight sided and so can not be fitted easily to structures such as the hippocampus which curve along their lengths. Smaller VOIs can be chosen but at the expense of poorer signal. Even small inconsistencies of VOI placement can impact on the quality of results by reducing the sensitivity to what are expected to be relatively small changes in metabolite concentrations with disease and treatment. Other factors which impact on the sensitivity include VOI size, acquisition time, single versus multi-voxel CSI MRS as well as pulse sequence parameters and analysis protocols. Coupled with this, efficacy studies of treatment regimes will require multicentre trials across MR systems produced by different manufacturers. Any optimisation of MRS acquisitions must therefore be robust enough to be applicable to all.  The aim of this project is therefore to rigorously develop and assess strategies to optimise and standardise MRS acquisitions to increase sensitivity to small changes in metabolites and pave the way for multicentre trials.