PET is Wonderful Annual Meeting 2020 Oct 27, 2020 02:00 PM - 05:40 PM — Virtual Meeting (online)
Through the Looking Glass: Breaking Barriers in STEM Oct 28, 2020 12:00 PM - 03:30 PM — Virtual Meeting (online)
NRS Mental Health Network Annual Scientific Meeting 2020 Nov 04, 2020 09:00 AM - 05:30 PM — Virtual Meeting (online)
Scottish Radiological Society Annual General Meeting 2020 Nov 06, 2020 09:30 AM - 03:30 PM — Virtual Meeting (online)
IPEM educational meeting: Artificial Intelligence in MRI Nov 18, 2020 12:00 AM — Virtual Meeting (online)

eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Adele Blair

Position:
Institute:
Department:


Description of Phd:

 

The translocator protein 18 kDa (TSPO, formerly known as the peripheral benzodiazepine receptor) is found at high levels in the kidney, lung, heart and at low concentration in the brain. TSPO is associated with initial inflammatory processes in the early stages of neurological diseases such as Parkinson’s and Alzheimer’s diseases and after brain injury caused by stroke or head trauma. TSPO has therefore significant potential as a marker of regions affected by these conditions. While radioligands have been developed for TSPO these suffer from high nonspecific binding and relatively low brain uptake. The aim of this project is to develop a new generation of molecular tracers which can act as effective imaging agents for TSPO. A new synthetic approach for the preparation of a small library of compounds based on the phenoxyphenylacetamide core structure will be developed and tested for affinity with TSPO. This will allow the development of a structure activity relationship model ultimately generating a lead compound which can radiolabelled for in vivo imaging of TSPO. An additional feature of this research programme will be the design of target compounds with multi-labelling positions allowing these compounds to be used for either PET and SPECT imaging (In collaboration with Dr Sally Pimlott, University of Glasgow). The structures of these compounds also have the potential to fluoresce and thus may find application in optical imaging. A significant portion of this PhD studentship will be carried out in the department of chemistry (GU), thus further strengthening the collaboration between the ScotCHEM and SINAPSE pooling initiatives. The research will be carried out in collaboration with Molecular NeuroImaging, MNI, a company based in Connecticut who develop radioligands as tools for drug development for neurodegenerative and neuropsychiatric disorders (Dr Gilles Tamagnan). MNI will consult on the key objectives of the research programme as well as provide a placement for the PhD student to experience the use of clinical trials and PET/SPECT radiochemistry in an industrial setting.