UK PET Chemistry Workshop on Radiotracer Dispensing Oct 21, 2022 09:00 AM - 05:00 PM — KCL, London
Scottish Radiotherapy Research Forum Nov 10, 2022 10:00 AM - 04:00 PM — University of Stirling
IPEM Advanced Neuro MRI Nov 15, 2022 09:00 AM - 05:00 PM — Birmingham


SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists. **Unfortunately these do not currently work in browsers**

Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Mr Efstratios Kokkalis

Position: SINAPSE PhD student
Institute: University of Dundee
Department: Institute for Medical Science and Technology

Description of Phd:

The concept of spiral laminar flow being the normal physiological arterial flow pattern has been based on physiological observations of the circulatory system. It is initiating and propagating by the way that the heart is twisted along its axis and the aortic arch is twisted, curved and tapered. This spiral laminar flow has been demonstrated by computer simulations of pulsatile flow in curved distensible vessels and by several published reports in a variety of anatomical locations.

The initial observations of in vivo spiral laminar flow stimulated the Vascular Flow Technologies (VFT) Ltd research into understanding the improved flow conditions achieved by spiral flow, such as the reduced near wall turbulent kinetic energy and the maintenance of wall shear stress in physiological level. The improved flow characteristics introduced by spiral flow is believed to prevent endothelial damage and thus to protect against both atheroma in native vessels and neo-intimal hyperplasia in implanted devices. VFT has developed vascular grafts with a spiral inducing segment in their distal end in order to reintroduce spiral flow. These grafts will be tested in flow phantoms and the flow pattern downstream the distal anastomosis will be assessed using imaging techniques. Control vascular grafts will be used for comparison. The key research questions of this project are: i) do these spiral grafts produce spiral flow pattern and how does this pattern differs from that detected in control grafts? ii) what is the impact of the spiral grafts on the distal haemodynamics which is relevant to atherosclerosis and what is their clinical significance?

    The output of the project will lead to the optimal configuration of the spiral grafts and will provide a better understanding of helical flow patterns after graft implantation.

    Key Publications
    1. Kokkalis E, Hoskins PR, Corner GA, Doull AJ, Stonebridge PA, Houston JG, “Hemodynamic differences in the outflow of access vascular grafts”, J Vasc Access 2013;14(1):47.
    2. E Kokkalis, PR Hoskins, GA Corner, PA Stonebridge, AJ Doull, JG Houston, “Vector Doppler maps and helical flow in the outflow of vascular prostheses”, British Medical Ultrasound Society 2012, UK.
    3. E Kokkalis, PR Hoskins, GA Corner, PA Stonebridge, AJ Doull, A Melzer, JG Houston, “Vector Doppler Imaging and Secondary Flow Patterns in Vascular Prostheses”, IEEE Int Ultrason Symp 2012;1894-7.
    4. E Kokkalis, PR Hoskins, GA Corner, PA Stonebridge, A Melzer, JG Houston, “Secondary flow motions in spiral and non-spiral vascular prostheses using ultrasound flow phantoms”, IPEM MPEC 2012, UK.
    5. MA Rube, E Kokkalis, E Immel, M Guerguieva, R Eisma, A Melzer, “Training and Testing Environment for MR-guided Vascular Interventions”, ISMRM, 2012, Australia.
    6. Z Qiu, E Kokkalis, S Cochran, “Development of an MRI-compatible focused ultrasound device for the treatment of rectal cancer”, Ultrasonic Industry Association 2011, UK.
    7. Α Tzavaras, B Spyropoulos, E Kokkalis, A Palaiologos, D Georgopoulos, G Prinianakis, M Botsivaly and PR Weller, "A Classification Attempt of COPD, ALI-ARDS and Normal Lungs of ventilated Patients through Compliance and Resistance over Time Waveform Discrimination", IFMBE Proc 2008;22:192-195.