Total Body PET 2021 conference [rescheduled] Sep 22, 2021 - Sep 24, 2021 — Virtual Meeting (online)
PET is Wonderful Annual Meeting 2021 Oct 26, 2021 12:00 AM — Virtual Meeting (online)
NRS Mental Health Network Annual Scientific Meeting 2021 Nov 02, 2021 09:00 AM - 05:00 PM — Royal College of Physicians, Edinburgh (and online)

eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Elizabeth Jameson

Position: SINAPSE PhD Student
Institute:
Department:


Description of Phd:

 

The focus of this project will be to develop a one-step labelling procedure suitable for the rapid and efficient labelling of a variety of probes with 18F fluoride or 68Ga. The key steps of all the proposed approaches will be:  (a). The generation of labelled material via a variety of PET-isotope mediated cleavage processes, giving rise to highly pure and concentrated samples. (b). The probes can be peptides thus allowing the approach to be applicable generically while the pre-probes can be made en masse and cleaved just when required (c). The liberation will be rapid and carried out in a flow manner. Three routes will be explored:  (i). The desired peptide pre-probe will be synthesised by solid phase methods, conjugated to a boronate carboxylic acid and then cleaved and purified. This will subsequently be captured onto a catechol derivatised resin. Treatment of the captured probe  (ideally a macroporous PS) with the fluoride source will cleave the probe off the support and give the stable boron fluoride label.1,2 (ii). The desired peptide pre-probe will be conjugated to an azido group, purified and captured onto a sulfonyl chloride resin that has been derivatised with an propargyl alcohol, using a Cu(I) catalysed [3+2] cycloaddition5. Treatment with the fluoride source will again cleave the probe off the support. (iii). As above the peptide will be synthesised, purified and then immobilised back on to a solid support. In this case the Ga(III) will induce co-ordination followed by resin mediated ester cleavage to give the desired liganded complex in solution.