Upcoming Events

A Celebration of the IDentIFY project and Ten Years of ABIC Oct 22, 2019 09:30 AM - 03:30 PM — Suttie Centre for Teaching & Learning in Healthcare, Medical School Campus, University of Aberdeen
4D flow MRI workshop Oct 22, 2019 12:30 PM - 04:30 PM — ICE Building, Queen Elizabeth University Hospital Glasgow
NRS Mental Health Network Annual Scientific Meeting 2019 Oct 29, 2019 09:00 AM - 04:30 PM — Technology Innovation Centre, 99 George Street, Glasgow
PET is Wonderful Annual Meeting 2019 Oct 29, 2019 09:00 AM - 05:00 PM — Royal Society of Edinburgh, 22-26 George Street, Edinburgh
Scottish Radiological Society Annual General Meeting 2019 Nov 01, 2019 12:00 AM — Principal Grand Central Hotel, Glasgow

SINAPSE Image of the Month: Manganese-enhanced MRI

September 2019 SINAPSE Image of the Month

Courtesy of Dr Scott Semple, this image shows cardiac MRI tissue characterisation in a patient with myocardial infarction, comparing native T1 mapping at left (A) with manganese-enhanced MRI (MEMRI) T1 mapping at right (B). Shortened T1 in remote myocardium is evident on MEMRI, discriminable from infarcted myocardium.

Manganese-based contrast agents in MRI reduce the T1 relaxation time of water, enabling contrast in tissues where it accumulates (such as the myocardium). As a calcium analogue, manganese is taken up avidly by voltage-gated calcium channels into cells with active calcium handling, therefore its uptake is absent in infarcted tissue. With its ability to label viable myocardium directly, and the natural occurrence of manganese in vivo making its safety and toxicity profile more attractive than gadolinium, MEMRI offers exciting potential for myocardial viability assessment and wider clinical translation.

 

The image is taken from a recent review published in Heart:

Spath NB, Thompson G, Baker AH, Dweck MR, Newby DE, Semple SIK. Manganese-enhanced MRI of the myocardium. Heart 2019; Epub ahead of print.