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Your search for Keyword: 'Diffusion imaging' returned 12 Result(s)
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Dr Simon R. Cox
Sean Denham
Dr John Foster
Miss Maria Goni
Mr Tristan Hollyer
Neural stem cell therapy for stroke: A rodent based project to identify potential MRI indices of functional recovery
Stroke is leading cause of severe disability in adults. The clot-buster, Alteplase is the only licensed drug available to treat acute stroke patients however, this is only available to a small percentage of total sufferers and must be administered within the first 4.5 hours after the onset of the stoke. Although substantial research has been carried out to develop new therapies for acute brain damage and chronic disability, the translation from bench-to-bedside has proved to be a significant hurdle.
Many groups have focused on administering stem cells of patient-own or external origin to enhance brain repair. The use of the conditionally immortalized human neural stem cell line CTX0E03 to treat sub-acute/chronic stroke is soon to enter Phase II clinical trials.
My project is an adjunct to existing pre-clinical work; aiming to understand how the cells improve recovery using clinically applicable MRI methodologies.
I have successfully developed functional tests suitable of detecting long term functional changes post stroke. With the support of Dr Jozien Goense, we have set up resting-state fMRI in the anaesthetised rodent. With this technique at our disposal, we hope to identify indices of functional improvement in resting-state sensorimotor networks and values derived from the diffusion tensor, which may correlated with improved sensorimotor function.
This is a SPIRIT funded studentship; the stem cell technology, surgical equipment, training and a contribution of supervision for this project are supplied by industrial partner, ReNeuron ltd. (Guildford, UK).
I am a registered STEM ambassador and have participated in outreach events with EuroStemCell.
Ms Shadia Mikhael
Dr Sankaranarayanan Ramachandran
Dr Arnab Rana
- Hippocampal atrophy
- Cognitive ageing
- Stroke
- Brain tumours
Shaun R. Stone
Shaun Stone is a final year Ph.D. ERC studying Medical Imaging at the University of Aberdeen under the supervision of Professor Alison Murray. He is the deputy student lead of the Image Analysis group of the Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE), a consortium of seven Scottish universities. His research is titled “Cognitive Reserve Estimation Models from Brain MRI in Healthy Ageing: A Machine Learning Approach”, under the supervision of Professor Alison D. Murray (University of Aberdeen), Dr Roger Staff (NHS), Professor Joanna Wardlaw, Professor Craig Ritchie (University of Edinburgh) and Dr Robin Wolz (IXICO). Cosupervisors to this project at Dr Gordon Waiter and Dr Anca Sandu-Giuraniuc. His project is funded by SINAPSE and industry partners IXICO.
His project aims to identify the most important MR imaging biomarkers that influence differences in cognitive resilience. That is, given the life-course of an individual, what are the imaging characteristics that allow us to predict increased risk of cognitive impairment? Further, what factors provide resilience against age- and disease-related brain changes? He is passionate about computational neuroscience, artificial intelligence and computer-assisted diagnosis in medical imaging. Shaun completed his undergraduate (BSc) degree in Psychology with Neuroscience, and postgraduate (MSc) degree in Neuroimaging at Bangor University, North Wales - where he gained experience using a range of neuroimaging techniques. Shaun continues to learn, using his neuro-background to transfer into computational medicine and diagnostic imaging and is looking forward to his future career in research or industry, thanks to this opportunity.
Professor Joanna Wardlaw
I am a senior academic neuroradiologist with a major interest in stroke, ageing and the effects of vascular disease on the brain as determined using imaging. I established the University of Edinburgh’s Brain Imaging Research Centre in 1998 and have maintained it as a major research resource since then. I am interested in research methodologies such as systematic reviews of diagnostic tests, analysis of imaging data, improving methods to extract pathophysiological information from imaging of the brain. My major interests are determining the pathophysiological mechanisms of cerebral small vessel disease in particular the role of the blood brain barrier versus ischaemia, and of large artery stroke, in particular determining the duration of salvageable tissue and modifiable secondary pathophysiological events at which new treatments could be targeted. I have been interested in thrombolysis for acute ischemic stroke since initiating a small RCT of intra-arterial thrombolysis (1990), and have maintained the Cochrane Database of Systematic Reviews review of Thrombolysis in Acute Ischaemic Stroke since then. I provided expert input to three multicentre thrombolysis in stroke trials (MAST-I, ECASS3 and IST-3). I have co-authored two highly regarded textbooks, numerous stroke guidelines and health economic assessments and provide teaching in neuroimaging for research through on-line MSc and CPD modules.
