People

I am a senior academic neuroradiologist with a major interest in stroke, ageing and the effects of vascular disease on the brain as determined using imaging. I established the University of Edinburgh’s Brain Imaging Research Centre in 1998 and have maintained it as a major research resource since then. I am interested in research methodologies such as systematic reviews of diagnostic tests, analysis of imaging data, improving methods to extract pathophysiological information from imaging of the brain. My major interests are determining the pathophysiological mechanisms of cerebral small vessel disease in particular the role of the blood brain barrier versus ischaemia, and of large artery stroke, in particular determining the duration of salvageable tissue and modifiable secondary pathophysiological events at which new treatments could be targeted. I have been interested in thrombolysis for acute ischemic stroke since initiating a small RCT of intra-arterial thrombolysis (1990), and have maintained the Cochrane Database of Systematic Reviews review of Thrombolysis in Acute Ischaemic Stroke since then. I provided expert input to three multicentre thrombolysis in stroke trials (MAST-I, ECASS3 and IST-3). I have co-authored two highly regarded textbooks, numerous stroke guidelines and health economic assessments and provide teaching in neuroimaging for research through on-line MSc and CPD modules.