For this PhD project, we are investigating the diagnostic potential of resting-state functional connectivity magnetic resonance imaging in minor stroke patients. According to the published literature, cortical reorganisation of neuronal networks plays a significant role in acute stroke in terms of regaining function. However, the underlying mechanisms involved in this process have not been fully elucidated. Thus, a better understanding of the neuronal reorganisation that takes place following a stroke will aid the diagnostic pathway and therefore contribute to the development of targeted therapies with the potential of promoting repair and reducing deficit.

Minor strokes are extremely common with a high risk of a serious recurrence taking place within the first days. These short duration ischaemic episodes pose a diagnostic challenge for clinicians, as their symptomatology can mimic other neurological conditions and a significant percentage of these patients can have an inconclusive imaging scan. This diagnostic uncertainty places a heavy burden on patients, clinicians and healthcare resources. Thus, assessing the clinical application of resting-state functional connectivity magnetic resonance imaging in this group of patients is of paramount importance.

• Varsou O, MacLeod MJ & Schwarzbauer C. Functional connectivity magnetic resonance imaging in stroke: an evidence-based clinical review. International Journal of Stroke: DOI: 10.1111/ijs.12033.