Upcoming Events

SINAPSE Image Analysis meeting Sep 20, 2017 10:30 AM - 03:30 PM — Wolfson Theatre, Queen Mother Building, University of Dundee
ERASMUS Course on MRI: Basic MRI Physics Sep 25, 2017 - Sep 29, 2017 — Ninewells Hospital Medical School, Dundee
7th SINAPSE-SANON Meeting Sep 28, 2017 09:30 AM - 04:00 PM — Wellcome Rooms, Royal Society of Edinburgh, 22-26 George Street, Edinburgh
ECCOMAS VipIMAGE 2017 Oct 18, 2017 - Oct 20, 2017 — Porto, Portugal
ESMRMB 2017 Congress Oct 19, 2017 - Oct 21, 2017 — Fira de Barcelona, Barcelona, Spain

People




Professor Lawrence Barsalou


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Miss Emma Bashford


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Dr Mark Bastin

Diffusion tensor MRI · Dynamic susceptibility contrast perfusion MRI · Magnetization transfer MRI · Quantitative spin-lattice relaxation (T1) measurement · Application to normal ageing, brain tumours, schizophrenia, bipolar disorder, MND and MS.

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Dr Satu Baylan

  • Neuropsychological assessment of memory, attention and executive functions in the context of brain injury and healthy ageing.
  • Cognitive rehabilitation interventions (eg Goal Management Training).
  • Functional imaging of the effects of cognitive rehabilitation interventions.
  • Treatment of mood disorders after stroke (music based interventions and positive psychotherapy).

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Professor Edwin van Beek

I am a clinical cardiothoracic radiologist with experience in lung, cardiovascular and oncologic imaging. I am interested in multidisciplinary research approaches with the application of novel imaging techniques and advanced quantitative software tools to provide better analysis of disease states and wish to develop imaging as a biomarker. In addition to the relatively traditional single organ system approach, I am interested in the interactions of these systems within the larger groups of diseases, including COPD, asthma, atherosclerosis and cancer. Towards this end, I intend to develop programs that will appeal to multiple specialities that may not currently be working together within a single group of researchers. Apart from these ideas and interests, I am trained in Clinical Epidemiology and am interested in developing Evidence Based Radiology into clinical practice and build this within the registrar training scheme. It is my firm belief that this will aid in developing an academic career pathway within Radiology. My current role is that of director of the clinical research imaging centre, which houses 3T MRI, 128 PET-CT and 320 detector row CT. This is supported by a GE cyclotron with a fully functional MHRA inspected GMP radiochemistry facility as well as a research laboratory, allowing clinical/research production as well as development of novel radiotracers. An integrated advanced image analysis laboratory completes the centre.

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Mr Samuel Bennett


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Mike Bewick


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Professor Luc Bidaut


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Dr Gordon Blair

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Adele Blair

Description of PhD:

 

The translocator protein 18 kDa (TSPO, formerly known as the peripheral benzodiazepine receptor) is found at high levels in the kidney, lung, heart and at low concentration in the brain. TSPO is associated with initial inflammatory processes in the early stages of neurological diseases such as Parkinson’s and Alzheimer’s diseases and after brain injury caused by stroke or head trauma. TSPO has therefore significant potential as a marker of regions affected by these conditions. While radioligands have been developed for TSPO these suffer from high nonspecific binding and relatively low brain uptake. The aim of this project is to develop a new generation of molecular tracers which can act as effective imaging agents for TSPO. A new synthetic approach for the preparation of a small library of compounds based on the phenoxyphenylacetamide core structure will be developed and tested for affinity with TSPO. This will allow the development of a structure activity relationship model ultimately generating a lead compound which can radiolabelled for in vivo imaging of TSPO. An additional feature of this research programme will be the design of target compounds with multi-labelling positions allowing these compounds to be used for either PET and SPECT imaging (In collaboration with Dr Sally Pimlott, University of Glasgow). The structures of these compounds also have the potential to fluoresce and thus may find application in optical imaging. A significant portion of this PhD studentship will be carried out in the department of chemistry (GU), thus further strengthening the collaboration between the ScotCHEM and SINAPSE pooling initiatives. The research will be carried out in collaboration with Molecular NeuroImaging, MNI, a company based in Connecticut who develop radioligands as tools for drug development for neurodegenerative and neuropsychiatric disorders (Dr Gilles Tamagnan). MNI will consult on the key objectives of the research programme as well as provide a placement for the PhD student to experience the use of clinical trials and PET/SPECT radiochemistry in an industrial setting.

 

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