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SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists. **Unfortunately these do not currently work in browsers**


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Online Short Courses

alpha 4 beta 2-nicotinic receptor binding with 5-IA in Alzheimer's disease: Methods of scan analysis

Author(s): E. Terriere, M. Sharman, C. Donaghey, L. Herrmann, J. Lonie, M. Strachan, N. Dougall, J. Best, K. P. Ebmeier, S. Pimlott, J. Patterson, D. Wyper

Abstract:
Five patients with Alzheimer's disease and five healthy volunteers were examined by SPECT with the nicotinic receptor ligand I-123-5-IA-85380. Patients were scanned before and after 6 weeks of treatment with donepezil. Quantification by regions of interest was reliable and the optimal normalisation procedure used cerebellar ratios. We found relative reductions in 5-IA binding capacity in patients in thalamus, frontal and central regions of interest of approximately one standard deviation unit (Cohen's d = 1). Reductions in binding after treatment with the acetylcholinesterase inhibitor donepezil of the same magnitude occurred in the brain stem. The study was clearly too small to confirm group differences, but it suggests that 5-IA can be used to examine both group differences and treatment effects in patients with Alzheimer's disease.

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 0364-3190
Publication Year: 2008
Periodical: Neurochemical Research
Periodical Number: 4
Volume: 33
Pages: 643-651
Author Address: