Scottish Radiological Society Spring Meeting 2021 May 14, 2021 09:00 AM - 05:00 PM — Virtual Meeting (online)
9th Annual Scottish Radiotherapy Research Forum Jun 03, 2021 12:30 PM - 05:00 PM — Virtual Meeting (online)
Medical Imaging Convention [rescheduled] Sep 15, 2021 - Sep 16, 2021 — National Exhibition Centre, Birmingham, England
Total Body PET 2021 conference [rescheduled] Sep 25, 2021 - Sep 27, 2021 — McEwan Hall, University of Edinburgh

eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

alpha 4 beta 2-nicotinic receptor binding with 5-IA in Alzheimer's disease: Methods of scan analysis

Author(s): E. Terriere, M. Sharman, C. Donaghey, L. Herrmann, J. Lonie, M. Strachan, N. Dougall, J. Best, K. P. Ebmeier, S. Pimlott, J. Patterson, D. Wyper

Abstract:
Five patients with Alzheimer's disease and five healthy volunteers were examined by SPECT with the nicotinic receptor ligand I-123-5-IA-85380. Patients were scanned before and after 6 weeks of treatment with donepezil. Quantification by regions of interest was reliable and the optimal normalisation procedure used cerebellar ratios. We found relative reductions in 5-IA binding capacity in patients in thalamus, frontal and central regions of interest of approximately one standard deviation unit (Cohen's d = 1). Reductions in binding after treatment with the acetylcholinesterase inhibitor donepezil of the same magnitude occurred in the brain stem. The study was clearly too small to confirm group differences, but it suggests that 5-IA can be used to examine both group differences and treatment effects in patients with Alzheimer's disease.

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 0364-3190
Publication Year: 2008
Periodical: Neurochemical Research
Periodical Number: 4
Volume: 33
Pages: 643-651
Author Address: