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SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.

Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Assessment of I-123-FIAU imaging of herpes simplex viral gene expression in the treatment of glioma

Author(s): M. F. Dempsey, D. Wyper, J. Owens, S. Pimlott, V. Papanastassiou, J. Patterson, D. M. Hadley, A. Nicol, R. Rampling, S. M. Brown

Background Herpes simplex virus 1716 (HSV1716), a selectively replication competent mutant of HSV1, is under investigation as an oncolytic viral therapy in human malignant glioma. As with similar therapies, a technique for measurement of viral replication and distribution over time following virus administration is required. Imaging expression of the HSV-thymidine kinase (HSV-tk) gene offers an opportunity for non-invasive assessment of viral distribution in living subjects. This is the first study to explore the use of HSV-tk as a reporter gene and radiolabelled thymidine analogue 5-[I-123] iodo-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil (I-123-FIAU) as a marker substrate to non-invasively monitor HSV1716 replication in humans during treatment of high-grade glioma. Methods I-123-FIAU brain SPECT imaging was undertaken in eight patients receiving intra-tumoural injection of HSV1716, before and after administration of the virus. Baseline images were acquired 3 days prior to virus administration and between 1 and 5 days following virus administration. Region of interest analysis was used to investigate whether there was an increase in I-123-FIAU concentration following virus administration due to HSV-tk expression. Result Increased I-123-FIAU accumulation due to HSV-tk expression was not detected in this study. The possible explanations for this finding are explored and design options for future studies are discussed.

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ISBN: 0143-3636
Publication Year: 2006
Periodical: Nuclear Medicine Communications
Periodical Number: 8
Volume: 27
Pages: 611-617
Author Address: