9th SINAPSE Neuro-oncology Imaging Meeting [rescheduled] Mar 11, 2021 09:30 AM - 03:30 PM — West Park Conferencing & Events, 319 Perth Road, Dundee DD2 1NN
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Medical Imaging Convention [rescheduled] Sep 15, 2021 - Sep 16, 2021 — National Exhibition Centre, Birmingham, England

eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

The asymmetric Bischler-Napieralski reaction: preparation of 1,3,4-trisubstituted 1,2,3,4-tetrahydroisoquinolines

Author(s): M. Nicoletti, D. O'Hagan, A. M. Z. Slawin

Abstract:
The Bischler-Napieralski reaction, which is used to prepare dihydroisoquinolines from phenylethylamides, is demonstrated by the reaction of (S)-1-alkyl-1,2-diphenylethylamides with POCl3-P2O5. The reaction generated 3-alkyl-4-phenyl-1,2-dihydroisoquinolines with stereochemical selectivities of 80-91% de depending on the alkyl and the acetamide substituents. These are the rst examples of the asymmetric Bischler-Napieralski reaction where cyclisation discriminates between two identical diastereotopic aryl groups. Reduction of the resultant dihydroisoquinoline products with LiAlH4 generated the corresponding 1,2,3,4-tetrahydroisoquinolines in a stereoselective manner, carrying three stereogenic centres at C(1), C(3) and C(4).

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 1472-7781
Publication Year: 2002
Periodical: Journal of the Chemical Society-Perkin Transactions 1
Periodical Number: 1
Volume:
Pages: 116-121
Author Address: