4th International Conference on Medical Imaging with Deep Learning Jul 07, 2021 - Jul 09, 2021 — Virtual Meeting (online)
Medical Image Understanding and Analysis Conference 2021 Jul 12, 2021 - Jul 14, 2021 — Virtual Meeting (online)
Medical Imaging Convention [rescheduled] Sep 15, 2021 - Sep 16, 2021 — National Exhibition Centre, Birmingham, England
2021 SINAPSE ASM Sep 16, 2021 - Sep 17, 2021 — Technology & Innovation Centre, University of Strathclyde, 99 George Street, Glasgow
Total Body PET 2021 conference [rescheduled] Sep 22, 2021 - Sep 24, 2021 — Virtual Meeting (online)


SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.

Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Cognitive correlates of cerebral white matter lesions and water diffusion tensor parameters in community-dwelling older people

Author(s): S. D. Shenkin, M. E. Bastin, T. J. MacGillivray, I. J. Deary, J. M. Starr, C. S. Rivers, J. M. Wardlaw

Background: The biological basis of cognitive ageing is unknown. One underlying process might be disruption of white matter tracts connecting cortical regions. White matter lesions (WML) seen on structural MRI may disrupt cortical connections, but diffusion tensor MRI (DT-MRI) parameters - mean diffusivity (<D>) and fractional anisotropy ( FA) - may reflect more subtle changes in white matter integrity. Here the relationships between WML load, DT-MRI parameters and cognition in a large cohort of elderly subjects with a very narrow age range were investigated. Methods: 105 community-dwelling volunteers underwent MRI and neuropsychological assessment. Seventy-two (68.6%) were female, and their mean age was 78.4 (SD 1.5) years. Scans were rated for WML load. <D> and FA were measured from regions of interest in normal-appearing frontal and occipital white matter, and centrum semiovale. Results: <D> and FA differed significantly among the three brain regions studied ( p << 0.01). <D> increased with age ( r = 0.22 to 0.35, p < 0.03), and was negatively correlated with FA ( r = - 0.20 to -0.51, p < 0.05) in all three regions. There was a trend towards increased WML load correlating with poorer cognitive function, and this was statistically significant for the Mini-Mental State Examination (rho = - 0.23, p = 0.02). <D> was generally negatively correlated with cognitive test score, and FA was positively correlated. This pattern was more consistent for <D> than for FA, and particularly for verbal fluency (<D>: r = - 0.22 to - 0.27, p < 0.03), which measures executive function. Conclusions: DT-MRI parameters, in particular <D>, are sensitive to early ultrastructural changes underlying cognitive ageing. Executive function may be the cognitive domain most sensitive to age-related decline in white matter tract integrity. Copyright (C) 2005 S. Karger AG, Basel.

Full version: Available here

Click the link to go to an external website with the full version of the paper

ISBN: 1015-9770
Publication Year: 2005
Periodical: Cerebrovascular Diseases
Periodical Number: 5
Volume: 20
Pages: 310-318
Author Address: