Scottish Radiological Society Spring Meeting 2021 May 14, 2021 09:00 AM - 05:00 PM — Virtual Meeting (online)
9th Annual Scottish Radiotherapy Research Forum Jun 03, 2021 12:30 PM - 05:00 PM — Virtual Meeting (online)
Medical Imaging Convention [rescheduled] Sep 15, 2021 - Sep 16, 2021 — National Exhibition Centre, Birmingham, England
Total Body PET 2021 conference [rescheduled] Sep 25, 2021 - Sep 27, 2021 — McEwan Hall, University of Edinburgh


SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.

Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Common variants near MC4R are associated with fat mass, weight and risk of obesity

Author(s): R. J. F. Loos, C. M. Lindgren, S. X. Li, E. Wheeler, J. H. Zhao, I. Prokopenko, M. Inouye, R. M. Freathy, A. P. Attwood, J. S. Beckmann, S. I. Berndt, S. Bergmann, A. J. Bennett, S. A. Bingham, M. Bochud, M. Brown, S. Cauchi, J. M. Connell, C. Cooper, G. D. Smith, I. Day, C. Dina, S. De, E. T. Dermitzakis, A. S. F. Doney, K. S. Elliott, P. Elliott, D. M. Evans, I. S. Farooqi, P. Froguel, J. Ghori, C. J. Groves, R. Gwilliam, D. Hadley, A. S. Hall, A. T. Hattersley, J. Hebebrand, I. M. Heid, B. Herrera, A. Hinney, S. E. Hunt, M. R. Jarvelin, T. Johnson, J. D. M. Jolley, F. Karpe, A. Keniry, K. T. Khaw, R. N. Luben, M. Mangino, J. Marchini, W. L. McArdle, R. McGinnis, D. Meyre, P. B. Munroe, A. D. Morris, A. R. Ness, M. J. Neville, A. C. Nica, K. K. Ong, S. O'Rahilly, K. R. Owen, C. N. A. Palmer, K. Papadakis, S. Potter, A. Pouta, L. Qi, J. C. Randall, N. W. Rayner, S. M. Ring, M. S. Sandhu, A. Scherag, M. A. Sims, K. Song, N. Soranzo, E. K. Speliotes, H. E. Syddall, S. A. Teichmann, N. J. Timpson, J. H. Tobias, M. Uda, C. I. G. Vogel, C. Wallace, D. M. Waterworth, M. N. Weedon, C. J. Willer, V. L. Wraight, X. Yuan, E. Zeggini, J. N. Hirschhorn, D. P. Strachan, W. H. Ouwehand, M. J. Caulfield, N. J. Samani, T. M. Frayling, P. Vollenweider, G. Waeber, V. Mooser, P. Deloukas, M. I. McCarthy, N. J. Wareham, I. Barroso, Ovarian Prostate Lung Colorectal, Kora, Study Nurses' Health, Initiative Diabetes Genetics, N. I. A. Study Sardi, Consor Wellcome Trust Case Control, Fusion

To identify common variants influencing body mass index (BMI), we analyzed genome-wide association data from 16,876 individuals of European descent. After previously reported variants in FTO, the strongest association signal (rs17782313, P = 2.9 x 10(-6)) mapped 188 kb downstream of MC4R (melanocortin-4 receptor), mutations of which are the leading cause of monogenic severe childhood-onset obesity. We confirmed the BMI association in 60,352 adults (per-allele effect = 0.05 Z-score units; P = 2.8 x 10(-15)) and 5,988 children aged 7-11 (0.13 Z-score units; P = 1.5 x 10(-8)). In case-control analyses (n = 10,583), the odds for severe childhood obesity reached 1.30 (P = 8.0 x 10(-11)). Furthermore, we observed overtransmission of the risk allele to obese offspring in 660 families (P (pedigree disequilibrium test average; PDT-avg) 2.4 x 10(-4)). The SNP location and patterns of phenotypic associations are consistent with effects mediated through altered MC4R function. Our findings establish that common variants near MC4R influence fat mass, weight and obesity risk at the population level and reinforce the need for large-scale data integration to identify variants influencing continuous biomedical traits.

Full version: Available here

Click the link to go to an external website with the full version of the paper

ISBN: 1061-4036
Publication Year: 2008
Periodical: Nature Genetics
Periodical Number: 6
Volume: 40
Pages: 768-775
Author Address: