PET is Wonderful Annual Meeting 2021 Oct 26, 2021 12:00 AM — Virtual Meeting (online)
NRS Mental Health Network Annual Scientific Meeting 2021 Nov 02, 2021 09:00 AM - 05:00 PM — Royal College of Physicians, Edinburgh (and online)
SRS Autumn Meeting 2021 Nov 12, 2021 08:30 AM - 04:00 PM — Dundee

eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Comparative distribution of binding of the muscarinic receptor ligands pirenzepine, AF-DX 384, (R,R)-I-QNB and (R,S)-I-QNB to human brain

Author(s): M. Piggott, J. Owens, J. O'Brien, S. Paling, D. Wyper, J. Fenwick, M. Johnson, R. Perry, E. Perry

Abstract:
Quinuclidinyl benzilate (QNB) and its derivatives are being developed to investigate muscarinic receptor changes in vivo in Alzheimer's disease and dementia with Lewy bodies. This is the first study of [I-125]-(R,R)-I-QNB and [I-125]-(R,S)-I-QNB binding in vitro in human brain. We have compared the in vitro binding of the muscarinic ligands [H-3]pirenzepine and [H-3]AF-DX 384, which have selectivity for the M1 and M2/M4 receptor subtypes, respectively, to the binding of [I-125]-(R,R)-I-QNB and [I-125]-(R,S)-I-QNB. This will provide a guide to the interpretation of in vivo SPET images generated with [I-123]-(R,R)-I-QNB and [I-123]-(R,S)-I-QNB. Binding was investigated in striatum, globus pallidus, thalamus and cerebellum, and cingulate, insula, temporal and occipital cortical areas, which show different proportions of muscarinic receptor subtypes, in post-mortem brain from normal individuals. M1 receptors are of high density in cortex and striatum and are relatively low in the thalamus and cerebellum, while M4 receptors are mainly expressed in the striatum, and M2 receptors are most evident in the cerebellum and thalamus. [I-125]-(R,R)-I-QNB and 1 [I-125]-(R,S)-I-QNB density distribution patterns were consistent with binding to both M1 and M4 receptors, with [I-125]-(R,R)-I-QNB additionally binding to a non-cholinergic site not displaceable by atropine. This distribution can be exploited by in vivo imaging, developing ligands for both SPET and PET, to reveal muscarinic receptor changes in Alzheimer's disease and dementia with Lewy bodies during the disease process and following cholinergic therapy. (C) 2002 Elsevier Science B.V. All rights reserved.

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 0891-0618
Publication Year: 2002
Periodical: Journal of Chemical Neuroanatomy
Periodical Number: 3
Volume: 24
Pages: 211-223
Author Address: