Data Sciences and Brain Health across the Life Course session in 2020 SICSA Conference Oct 01, 2020 01:15 PM - 03:15 PM — Virtual Meeting (online)
Ophthalmic Medical Image Analysis MICCAI 2020 Workshop Oct 08, 2020 12:00 AM — Virtual Meeting (online)
Predictive Intelligence in Medicine MICCAI 2020 Workshop Oct 08, 2020 12:00 AM — Virtual Meeting (online)
PET is Wonderful Annual Meeting 2020 Oct 27, 2020 02:00 PM - 05:40 PM — Virtual Meeting (online)

eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Crystallization and X-ray diffraction of 5 '-fluoro-5 '-deoxyadenosine synthase, a fluorination enzyme from Streptomyces cattleya

Author(s): C. J. Dong, H. Deng, M. Dorward, C. Schaffrath, D. O'Hagan, J. H. Naismith

Abstract:
Organofluorine compounds are widely prepared throughout the chemicals industry, but their prepararion generally requires harsh fluorinating reagents and non-aqueous solvents. On the other hand, biology has hardly exploited organofluorine compounds. A very few organisms synthesize organofluorine metabolites, suggesting they have evolved a mechanism to overcome the kinetic desolvation barrier to utilizing F-(aq). Here, the purification and crystallization of an enzyme from Streptomyces cattleya which is responsible for the synthesis of the C-F bond during fluoroacetate and 4-fluorothreonine biosynthesis is reported. The protein crystallizes in space group C222(1), with unit-cell parameters a = 75.9, b = 130.3, c = 183.4 Angstrom, alpha = beta = gamma = 90degrees. Data were recorded to 1.9 Angstrom at the ESRF. The structure of the protein should provide important insights into the biochemical process of C-F bond formation.

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 0907-4449
Publication Year: 2003
Periodical: Acta Crystallographica Section D-Biological Crystallography
Periodical Number:
Volume: 59
Pages: 2292-2293
Author Address: