Scottish Radiological Society Spring Meeting 2021 May 14, 2021 09:00 AM - 05:00 PM — Virtual Meeting (online)
9th Annual Scottish Radiotherapy Research Forum Jun 03, 2021 12:30 PM - 05:00 PM — Virtual Meeting (online)
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eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Detection of radiation-induced lung injury in non-small cell lung cancer patients using hyperpolarized helium-3 magnetic resonance imaging

Author(s): R. H. Ireland, O. S. Din, J. A. Swinscoe, N. Woodhouse, E. J. R. van Beek, J. M. Wild, M. Q. Hatton

Abstract:
Purpose: To compare hyperpolarized helium-3 margnetic resonance imaging (He-3-MRI) acquired from non-small cell lung cancer (NSCLC) patients before and after external beam radiotherapy (EBRT). Methods and materials: In a ethics Committee-approved prospective study, five patients with histologically confirmed NSCLC gave written informed consent to undergo computed tomography (CT) and He-3-MR ventilation imaging 1 week prior to and 3 months after radiotherapy. Images were registered to pre-treatment CT using anatomical landmark-based rigid registration to enable comparison. Emphysema was graded from examination of the CT. MRI-defined ventilation was calculated as the intersection of He-3-MRI and CT lung volume as a percentage of the CT lung volume for the whole lung and regions of CT-defined pneumonitis. Results: On pre-treatment images, there was a significant correlation between the degree of CT-defined emphysema and He-3-MRI whole lung ventilation (Spearman's rho = 0.90, p = 0.04). After radiation therapy, pneumonitis was evident on CT for 3/5 patients. For these cases. He-3-MRI ventilation was significantly reduced within the regions of pneumonitis (pre: 94.1 +/- 2.2%, post: 73.7 +/- 4.7%; matched pairs Student's t-test, p = 0.02, mean difference = 20.4%, 95% confidence interval 6.3-34.6%). Conclusions: This work demonstrates the feasibility of detecting ventilation changes between pre- and post-treatment using hyperpolarized helium-3 MRI for detecting ventilation changes between pre- and post-treatment using hyperpolarized helium-3 MRI for patients with NSCLC. Pre-treatment, the degree of emphysema and He-3-MRI ventilation were correlated. For three cases of radiation pneumonitis, He-3-MRI ventilation changes between pre- and post-treatment imaging were consistent with CT evidence of radiation-induced lung injury (C) 2010 Elsevier Ireland Ltd. All rights reserved. Randiotherapy and Oncology 97 (2010) 244-248

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 0167-8140
Publication Year: 2010
Periodical: Radiotherapy and Oncology
Periodical Number: 2
Volume: 97
Pages: 244-248
Author Address: