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eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


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Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

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Online Short Courses

Effect of timing and method of enteral tube feeding for dysphagic stroke patients (FOOD): a multicentre randomised controlled trial

Author(s): J. Clarke, G. Cranswick, M. S. Dennis, R. Flaig, A. Fraser, S. Grant, A. Gunkel, J. Hunter, S. Lewis, D. Perry, V. Soosay, C. Williams, A. Williamson, A. Young, C. J. Bulpitt, A. Grant, G. Murray, P. Sandercock, N. Anderson, S. Bahar, G. Hankey, S. Ricci, G. Bathgate, C. Chalmers, B. Farrell, J. Forbes, S. Ghosh, P. Langhorne, S. Levis, J. MacIntyre, C. A. McAteer, P. O'Neill, J. Potter, M. Roberts, C. Warlow, S. C. Lewis, Food Trial Collaboration

Abstract:
Background Undernutrition is common inpatients admitted with stroke. We aimed to establish whether the timing and route of enteral tube feeding after stroke affected patients' outcomes at 6 months. Methods The FOOD trials consist of three pragmatic multicentre randomised controlled trials, two of which included dysphagic stroke patients. In one trial, patients enrolled within 7 days of admission were randomly allocated to early enteral tube feeding or no tube feeding for more than 7 days (early versus avoid). In the other, patients were allocated percutaneous endoscopic gastrostomy (PEG) or nasogastric feeding. The primary outcome was death or poor outcome at 6 months. Analysis was by intention to treat. Findings Between Nov 1, 1996, and July 31, 2003, 859 patients were enrolled by 83 hospitals in 15 countries into the early versus avoid trial. Early tube feeding was associated with an absolute reduction in risk of death of 5 . 8% (95% CI -0 . 8 to 12 . 5, p=0.09) and a reduction in death or poor outcome of 1 . 2% (-4.2 to 6.6, p=0.7). In the PEG versus nasogastric tube trial, 321 patients were enrolled by 47 hospitals in 11 countries. PEG feeding was associated with an absolute increase in risk of death of 1 . 0% (-10 . 0 to 11 . 9, p=0 . 9) and an increased risk of death or poor outcome of 7.8% (0 . 0 to 15 . 5, p=0 . 05). Interpretation Early tube feeding might reduce case fatality, but at the expense of increasing the proportion surviving with poor outcome. Our data do not support a policy of early initiation of PEG feeding in dysphagic stroke patients.

Full version: Available here

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ISBN: 0140-6736
Publication Year: 2005
Periodical: Lancet
Periodical Number: 9461
Volume: 365
Pages: 764-772
Author Address: