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eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

The effects of a neuregulin 1 variant on white matter density and integrity

Author(s): A. M. McIntosh, T. W. Moorhead, D. Job, G. K. Lymer, S. Munoz Maniega, J. McKirdy, J. E. Sussmann, B. J. Baig, M. E. Bastin, D. Porteous, K. L. Evans, E. C. Johnstone, S. M. Lawrie, J. Hall

Abstract:
Theories of abnormal anatomical and functional connectivity in schizophrenia and bipolar disorder are supported by evidence from functional magnetic resonance imaging (MRI), structural MRI and diffusion tensor imaging (DTI). The presence of similar abnormalities in unaffected relatives suggests such disconnectivity is genetically mediated, albeit through unspecified loci. Neuregulin 1 (NRG1) is a psychosis susceptibility gene with effects on neuronal migration, axon guidance and myelination that could potentially explain these findings. In the current study, unaffected subjects were genotyped at the NRG1 single nucleotide polymorphism (SNP) rs6994992 (SNP8NRG243177) locus, previously associated with increased risk for psychosis, and the effect of genetic variation at this locus on white matter density (T(1)-weighted MRI) and integrity (DTI) was ascertained. Subjects with the risk-associated TT genotype had reduced white matter density in the anterior limb of the internal capsule and evidence of reduced structural connectivity in the same region using DTI. We therefore provide the first imaging evidence that genetic variation in NRG1 is associated with reduced white matter density and integrity in human subjects. This finding is discussed in the context of NRG1 effects on neuronal migration, axon guidance and myelination.

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 1476-5578 (Electronic) 1359-4184 (Linking)
Publication Year: 2008
Periodical: Mol Psychiatry
Periodical Number: 11
Volume: 13
Pages: 1054-9
Author Address: Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK. andrew.mcintosh@ed.ac.uk