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eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Engineering Fluorometabolite Production: Fluorinase Expression in Salinispora tropica Yields Fluorosalinosporamide

Author(s): A. S. Eustaquio, D. O'Hagan, B. S. Moore

Abstract:
Organofluorine compounds play an important role in medicinal chemistry, where they are responsible for up to 15% of the pharmaceutical products oil the market, While natural products are Valuable sources of new chemical entities, natural fluorinated Molecules are extremely rare and the pharmaceutical industry has not benefited from a microbial source of this class of compounds. Streptomyces cattleya is all unusual bacterium in that it elaborates fluoroacetate and the amino acid 4-fluorothreonine. The discovery in 2002 of the fluorination enzyme FIA responsible for C-F bond formation in S. cattleya. and its subsequent characterization, opened Lit) for the first time the prospect Of genetically engineering fluorometabolite production front fluoride ion in host organisms. As a proof of principle, we report here the induced production of fluorosalinosporamide by replacing the chlorinase gene salL from Solinispora tropica with the fluorinase gene flA.

Full version: Available here

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ISBN: 0163-3864
Publication Year: 2010
Periodical: Journal of Natural Products
Periodical Number: 3
Volume: 73
Pages: 378-382
Author Address: