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eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Enzymatic fluorination in Streptomyces cattleya takes place with an inversion of configuration consistent with an S(N)2 reaction mechanism

Author(s): C. D. Cadicamo, J. Courtieu, H. Deng, A. Meddour, D. O'Hagan

Abstract:
The stereochemical course of the recently isolated fluorination enzyme from Streptomyces cattleya has been evaluated. The enzyme mediates a reaction between fluoride ion and S-adenosyl-L-methionine (SAM) to generate 5'-fluoro-5'-deoxy-adenosine (5'-FDA). Preparation of (5'R)-[5-H-2(1)]-ATP generated (5'-R)-[5-H-2(1)]-5'-FDA in a coupled enzyme assay involving SAM synthase and the fluorinase. The stereochemical analysis of the product relied on H-2 NMR analysis in a chiral liquid-crystalline medium. It is concluded that the enzyme catalyses the fluorination with an inversion of configuration consistent with an S(N)2 reaction mechanism.

Full version: Available here

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ISBN: 1439-4227
Publication Year: 2004
Periodical: Chembiochem
Periodical Number: 5
Volume: 5
Pages: 685-690
Author Address: