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eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

The first enzymatic method for C-F-18 bond formation: the synthesis of 5 '-[F-18]-fluoro-5 ' deoxyadenosine for imaging with PET

Author(s): L. Martarello, C. Schaffrath, H. Deng, A. D. Gee, A. Lockhart, D. O'Hagan

Abstract:
The use of the key enzyme involved in carbon-fluorine bond formation in Streptomyces cattleya catalysing the formation of 5'-fluoro-5'-deoxyadenosine (5'-FDA) from fluoride ion and S-adenosyl-L-methionine (SAM) was explored for its potential application in fluorine-18 labelling of the adenosine derivative. Enzymatic radiolabelling of [F-18]-5'-FDA was successfully carried out starting from SAM and [F-18]HF when the concentration of the enzyme preparation was increased from sub-mg/ml values to mg/ml values. The purity of the enzyme had no measurable effect on the radiochemical yield of the reaction and the radiochemical purity of [F-18]-5'-FDA. Copyright (C) 2003 John Wiley Sons, Ltd.

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 0362-4803
Publication Year: 2003
Periodical: Journal of Labelled Compounds & Radiopharmaceuticals
Periodical Number: 13
Volume: 46
Pages: 1181-1189
Author Address: