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eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Fluorine in medicinal chemistry: beta-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA

Author(s): N. H. Campbell, D. L. Smith, A. P. Reszka, S. Neidle, D. O'Hagan

Abstract:
Comparative X-ray structure studies reveal that C-F bond incorporation into the peripheral pyrrolidine moieties of the G-quadruplex DNA binding ligand BSU6039 leads to a distinct pyrrolidine ring conformation, relative to the non-fluorinated analogue, and with a different binding mode involving reversal of the pyrrolidinium N+-H orientation.

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 1477-0520
Publication Year: 2011
Periodical: Organic & Biomolecular Chemistry
Periodical Number: 5
Volume: 9
Pages: 1328-1331
Author Address: