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Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task

Author(s): V. E. Gountouna, D. E. Job, A. M. McIntosh, T. W. J. Moorhead, G. K. L. Lymer, H. C. Whalley, J. Hall, G. D. Waiter, D. Brennan, D. J. McGonigle, T. S. Ahearn, J. Cavanagh, B. Condon, D. M. Hadley, I. Marshall, A. D. Murray, J. D. Steele, J. M. Wardlaw, S. M. Lawrie

Abstract:
Multicentre MRI studies offer great potential to increase Study power and flexibility, but it is not yet clear how reproducible the results from multiple centres may be. Here we present results from the multicentre Study 'CaliBrain', examining the reproducibility of fMRI data within and between three sites. Fourteen Subjects were scanned twice on three 1.5 T GE scanners using an identical scanning protocol. We present data from a motor task with three conditions, sequential and random finger tapping and rest. Similar activation maps were obtained for each site and visit; brain areas consistently activated during the task included the premotor, primary motor and supplementary motor areas, the striatum and cerebellum. Reproducibility was evaluated within and between sites by comparing the extent and spatial agreement of activation maps at both the subject and group levels. The results were within the range previously reported for similar tasks on single scanners and both measures were found to be comparable within and between sites, with between site reproducibility similar to the within site measures. A variance components analysis was used to examine the effects of site, subject and visit. The contributions of site and visit were small and reproducibility was similar between and within sites, whereas the variance between subjects, and unexplained variance was large. These findings suggest that we can have confidence in combined results from multicentre fMRI studies, at least when a consistent protocol is followed on similar machines in all participating scanning sites and care is taken to select homogeneous subject groups. (C) 2009 Elsevier Inc. All rights reserved.

Full version: Available here

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ISBN: 1053-8119
Publication Year: 2010
Periodical: Neuroimage
Periodical Number: 1
Volume: 49
Pages: 552-560
Author Address: Job, DE Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland Univ Edinburgh, Div Clin Neurosci, Edinburgh EH10 5HF, Midlothian, Scotland Univ Edinburgh, Dept Med Phys, Edinburgh EH10 5HF, Midlothian, Scotland Univ Dundee, Ctr Neurosci, Div Med Sci, Dundee DD1 4HN, Scotland Univ Aberdeen, Dept Radiol, Aberdeen AB9 1FX, Scotland Univ Glasgow, Fac Med, Div Community Based Sci, Dept Clin Phys, Glasgow G12 8QQ, Lanark, Scotland Univ Glasgow, Fac Med, Div Community Based Sci, Sackler Inst Psychobiol Res, Glasgow G12 8QQ, Lanark, Scotland Univ Glasgow, Dept Neurosci & Clin Radiol, Glasgow G12 8QQ, Lanark, Scotland Univ Edinburgh, Sch Psychol, Edinburgh EH8 9YL, Midlothian, Scotland Univ Edinburgh, Sch Biosci, Edinburgh EH8 9YL, Midlothian, Scotland Western Gen Hosp, Ctr Funct Imaging Studies, Edinburgh EH4 2XU, Midlothian, Scotland