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eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Kinetic modelling of [I-123]CNS 1261 - a potential SPET tracer for the NMDA receptor

Author(s): K. Erlandsson, R. A. Bressan, R. S. Mulligan, R. N. Gunn, V. J. Cunningham, J. Owens, D. Wyper, P. J. Ell, L. S. Pilowsky

Abstract:
N-(1-napthyl)-N'-(3-[I-123]-iodophenyl)-N-methylguanidine ([I-123]CNS 1261) is a novel SPET ligand developed for imaging the NMDA receptor intra-channel MK 801/PCP/ketamine site. Data was acquired in 7 healthy volunteers after bolus injection of [I-123]CNS 1261. Kinetic modeling showed reversible tracer binding. Arterial and venous time-activity curves overlapped after 90 min. The rank order of binding was: Thalamus > striatum > cortical regions > white matter. This distribution concurs with [C-11]-ketamine and [F-18]-memantine PET studies [14,1]. These data provide a methodological basis for further direct in vivo challenge studies. (C) 2003 Elsevier Inc. All rights reserved.

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 0969-8051
Publication Year: 2003
Periodical: Nuclear Medicine and Biology
Periodical Number: 4
Volume: 30
Pages: 441-454
Author Address: