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eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists. **Unfortunately these do not currently work in browsers**


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Online Short Courses

Magnesium in stroke treatment

Author(s): K. W. Muir

Abstract:
Magnesium is involved in multiple physiological processes that may be relevant to cerebral ischaemia, including antagonism of glutamate release, NMIDA receptor blockade, calcium channel antagonism, and maintenance of cerebral blood flow. Systemically administered magnesium at doses that double physiological serum concentration significantly reduces infarct volume in animal models of stroke, with a window of up to six hours after onset and favourable dose-response characteristics when compared with previously tested neuroprotective agents. Small clinical trials have reported benefit, but results are not statistically significant in systematic review. A large ongoing trial (IMAGES) will report in 2003-4 and further trials are planned.

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 0032-5473
Publication Year: 2002
Periodical: Postgraduate Medical Journal
Periodical Number: 925
Volume: 78
Pages: 641-645
Author Address: