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New iodinated quinoline-2-carboxamides for SPECT imaging of the translocator protein

Author(s): L. Stevenson, A. A. S. Tavares, A. Brunet, F. I. McGonagle, D. Dewar, S. L. Pimlott, A. Sutherland

With the aim of developing new SPECT imaging agents for the translocator protein (TSPO), a small library of iodinated quinoline-2-carboxamides have been prepared and tested for binding affinity with TSPO. N,N-Diethyl-3-iodomethyl-4-phenylquinoline-2-carboxamide was found to have excellent affinity (K-i 12.0 nM), comparable to that of the widely used TSPO imaging agent PK11195. (c) 2009 Elsevier Ltd. All rights reserved.

Full version: Available here

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ISBN: 0960-894X
Publication Year: 2010
Periodical: Bioorganic & Medicinal Chemistry Letters
Periodical Number: 3
Volume: 20
Pages: 954-957
Author Address: