Total Body PET 2021 conference [rescheduled] Sep 22, 2021 - Sep 24, 2021 — Virtual Meeting (online)
PET is Wonderful Annual Meeting 2021 Oct 26, 2021 12:00 AM — Virtual Meeting (online)
NRS Mental Health Network Annual Scientific Meeting 2021 Nov 02, 2021 09:00 AM - 05:00 PM — Royal College of Physicians, Edinburgh (and online)

eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Nicotinic alpha 4 beta 2 receptor binding in dementia with Lewy bodies using I-123-5IA-85380 SPECT demonstrates a link between occipital changes and visual hallucinations

Author(s): J. T. O'Brien, S. J. Colloby, S. Pakrasi, E. K. Perry, S. L. Pimlott, D. J. Wyper, I. G. McKeith, E. D. Williams

Abstract:
Introduction: To investigate in vivo differences in the distribution of alpha 4 beta 2 subtypes of nAChR using the ligand I-123-5-Iodo-3-[2(S)-2-azetidinylmethoxy] pyridine (5IA-85380) and single photon emission computed tomography (SPECT) in DLB and similarly aged controls. Methods: Thirty-one subjects (15 DLB and 16 controls) underwent I-123-5IA-85380 and perfusion (Tc-99m-exametazime) SPECT scanning. Patient scans were compared to scans of control subjects on a voxel-by-voxel basis using SPM2. Results: Compared to controls, significant reductions in relative I-123-5IA-85380 uptake were identified in frontal, striatal, temporal and cingulate regions in DLB. Elevation of scaled I-123-5IA-85380 uptake in occipital cortex was observed in DLB relative to controls, as well as being associated with DLB subjects with a recent history of visual hallucinations. Changes in I-123-5IA-85380 SPECT in DLB were different from perfusion. Conclusion: Reductions in normalised I-123-5IA-85380 uptake in DLB were distinct from their perfusion deficits. Significant increase in occipital lobe uptake was present in DLB, a change most pronounced in subjects with a recent history of visual hallucinations. The findings directly link cholinergic changes in occipital lobe to visual hallucinations in DLB. (C) 2008 Elsevier Inc. All rights reserved.

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 1053-8119
Publication Year: 2008
Periodical: Neuroimage
Periodical Number: 3
Volume: 40
Pages: 1056-1063
Author Address: