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eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Parkinson's Disease is Overdiagnosed Clinically at Baseline in Diagnostically Uncertain Cases: A 3-Year European Multicenter Study with Repeat [I-123]FP-CIT SPECT

Author(s): V. L. Marshall, C. B. Reininger, M. Marquardt, J. Patterson, D. M. Hadley, W. H. Oertel, H. T. S. Benamer, P. Kemp, D. Burn, E. Tolosa, J. Kulisevsky, L. Cunha, D. Costa, J. Booij, K. Tatsch, K. R. Chaudhuri, G. Ulm, O. Pogarell, H. Hoffken, A. Gerstner, D. G. Grosset

Abstract:
Over-diagnosis of Parkinson's disease (PD) is suggested by specialist review of community diagnosis, and in postmortem studies. In specialist centers 4 to 15% of patients entered into clinical trials as early PD do not have functional imaging support for a PD diagnosis. In a European multicenter prospective, longitudinal study, we compared clinical diagnosis with functional SPECT imging using [(123)-I]FP-CIT (DaTSCAN (TM). GE Healthcare). Repeat observations were performed over 3 years in patients with tremor and/or parkinsonism in whom there was initial diagnostic uncertainty between degenerative parkinsonism and nondegenerative tremor disorders. Video-recording of clinical features was scores independently of functional imaging results by two blinded clinicians at 36 months (= gold standard clincial diagnosis). Three readers, unaware of the clincial diagnosis, classified the images as normal or abnormal by visual inspection. The main endpoint was the sensitivity and specificity of SPECT imaging at baseline compared with the gold standard. In 99 patients completing the three serial assessments, on-site clinical diagnosis overdiagnosed degenerative parkinsonism at baseline in diagnostically uncertain cases compared with the gold standard clinical diagnosis (at 36 months), the latter giving sensitivity of 93% and specificity of 46%. The corresponding baseline [(123)-I]FP-CIT SPECT results showed a mean sensitivity of 78% and a specificity of 97%. Inter-reader agreement for rating scans as normal or abnormal was high (Cohen's (kappa) over cap = 0.94-0.97). (C) 2008 Movement Disorder Society

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 0885-3185
Publication Year: 2009
Periodical: Movement Disorders
Periodical Number: 4
Volume: 24
Pages: 500-508
Author Address: