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SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


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PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

A qualitative test of the balloon model for BOLD-based MR signal changes at 3T

Author(s): T. Mildner, D. G. Norris, C. Schwarzbauer, C. J. Wiggins

Abstract:
The aim of this study was to adapt the balloon model for BOLD-based MR signal changes to a magnetic field strength of 3T and to examine its validity. The simultaneous measurement of BOLD and diffusion-weighted BOLD responses was performed. The amplitude of the BOLD peak was found to be similar for all subjects when a short visual stimulus of 6 sec was used. The rise-time to the BOLD peak and the shape and depth of the poststimulus undershoot varied significantly. A fit of the experimental BOLD responses was found to be possible by use of parameters within a reasonable physiological range. The relations between these parameters and their influence on the modeled BOLD responses is discussed. A prediction of the balloon model is the occurrence of a BOLD overshoot, i.e., a lag between the changes of the blood volume and the blood flow after the start of the stimulation. Experimental evidence for the existence of a BOLD overshoot is presented. (C) 2001 Wiley-Liss, Inc.

Full version: Available here

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ISBN: 0740-3194
Publication Year: 2001
Periodical: Magnetic Resonance in Medicine
Periodical Number: 5
Volume: 46
Pages: 891-899
Author Address: