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SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.

Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Samarium(II)-mediated 4-exo-trig cyclisations of unsaturated aldehydes. A stereoselective approach to functionalised cyclobutanols

Author(s): D. Johnston, C. F. McCusker, K. Muir, D. J. Procter

gamma,delta-Unsaturated aldehydes having a fully substituted centre in either the alpha- or beta-positions, have been prepared from substituted gamma-butyrolactones and undergo efficient 4-exo-trig cyclisation on treatment with samarium(II) iodide to give functionalised cyclobutanols. In all cases cyclisation occurs with complete diastereocontrol to give anti-cyclobutanol products. The stereochemistry of the products has been confirmed by NOE and X-ray crystallographic studies. In the cyclisation of substrates having a third substituent on the double bond, alpha- to the ester, significant control is achieved at the third newly formed stereocentre lying outside the ring. The origin of the stereoselectivity at this third centre and its marked dependence on cosolvent are discussed.

Full version: Available here

Click the link to go to an external website with the full version of the paper

ISBN: 0300-922X
Publication Year: 2000
Periodical: Journal of the Chemical Society-Perkin Transactions 1
Periodical Number: 5
Pages: 681-695
Author Address: