2020 SINAPSE ASM Jun 19, 2020 09:00 AM - 05:00 PM — Virtual Meeting (online)
3rd International Conference on Medical Imaging with Deep Learning Jul 06, 2020 - Jul 08, 2020 — Virtual Meeting (online)
Medical Image Understanding and Analysis Conference 2020 Jul 15, 2020 - Jul 17, 2020 — Virtual Meeting (online)
CAFACHEM 2020 Summer School on Organic & Halogen Radiochemistry Aug 25, 2020 - Aug 28, 2020 — KCL Waterloo Campus, London
Scottish Dementia Research Consortium Annual Conference 2020 [rescheduled] Sep 07, 2020 10:00 AM - 04:00 PM — Radisson Blu, 301 Argyle St, Glasgow


SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.

Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Sensible approaches for reducing clinical trial costs

Author(s): E. L. Eisenstein, R. Collins, B. S. Cracknell, O. Podesta, E. D. Reid, P. Sandercock, Y. Shakhov, M. L. Terrin, M. A. Sellers, R. M. Califf, C. B. Granger, R. Diaz

Background Over the past decade, annual funding for biomedical research has more than doubled while new molecular entity approvals have declined by one third. Objective To assess the value of practices commonly employed in the conduct of large-scale clinical trials, and to identify areas where costs could be reduced without compromising scientific validity. Methods In the qualitative phase of the study, an expert panel recommended potential modifications of mega-trial designs and operations in order to maximize their value (cost versus scientific benefit tradeoff). In the quantitative phase, a mega-trial economic model was used to assess the financial implications of these recommendations. Our initial chronic disease trial design included 20,000 patients randomized at 1000 sites. Each site was assigned 24 monitoring visits and a $10,000 per patient site payment. The case report form (CRF) was 60 pages long, and trial duration was assumed to be 48 months. Results The total costs of the initial trial design were $421 million ($US 2007). Following the expert panel's recommendations, we varied study duration, CRF length, number of sites, electronic data capture (EDC), and site management components to determine their individual and combined effects upon total trial costs. The use of EDC and modified site management practices were associated with significant reductions in total trial costs. When reductions in all five trial components were combined in a streamlined pharmaceutical industry design, a 59% reduction in total trial costs resulted. When we assumed an even more streamlined trial design than has typically been considered for regulatory submissions in the past, there was a 90% reduction in total trial costs. Conclusion Our results suggest that it is possible to reduce substantially the cost of large-scale clinical trials without compromising the scientific validity of their results. If implemented, our recommendations could free billions of dollars annually for additional clinical studies. Research in the setting of clinical trials should be conducted to refine these findings.

Full version: Available here

Click the link to go to an external website with the full version of the paper

ISBN: 1740-7745
Publication Year: 2008
Periodical: Clinical Trials
Periodical Number: 1
Volume: 5
Pages: 75-84
Author Address: