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eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Solid state and theoretical evaluation of beta-fluoroethyl esters indicate a fluorine-ester gauche effect

Author(s): C. R. S. Briggs, D. O'Hagan, H. S. Rzepa, A. M. Z. Slawin

Abstract:
Single crystal X-ray diffraction studies and a theoretical analysis indicate a preferred conformation for O-beta-fluoroethyl esters, where the C-F and C-O(CO) bonds are gauche rather than anti to each other. The O-C-C-F dihedral angles for three compounds and five independent structures indicate a range of only 63.4-69.6degrees. Evaluation of a rotational energy profile around this bond in a model system (beta-fluoroethyl acetate) predicted a similar dihedral angle and the gauche conformation to be the minimum on the rotational energy profile. High level ab initio calculations measured the gauche conformer to be 0.95 kcal mol(-1) lower in energy than the anti conformer and application of a solvation model further increased this differential to 1.6 kcal mol(-1), consistent with a previous solution state (NMR) evaluation of this system. (C) 2003 Elsevier B.V. All rights reserved.

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 0022-1139
Publication Year: 2004
Periodical: Journal of Fluorine Chemistry
Periodical Number: 1
Volume: 125
Pages: 19-25
Author Address: