2nd Scottish Ultrasound Annual Scientific Meeting Feb 28, 2020 10:00 AM - 05:00 PM — Collins Building, University of Strathclyde
Technology Innovations for Healthcare Mar 12, 2020 09:00 AM - 05:00 PM — Royal College of Physicians, Edinburgh
8th Annual Scottish Radiotherapy Research Forum Mar 12, 2020 10:00 AM - 04:30 PM — Stirling Court Hotel, University of Stirling
Medical Imaging Convention 2020 Mar 17, 2020 10:00 PM - 04:00 PM — National Exhibition Centre, Birmingham, England
9th SINAPSE Neuro-oncology Imaging Meeting Mar 19, 2020 09:30 AM - 03:30 PM — West Park Conferencing & Events, 319 Perth Road, Dundee DD2 1NN


SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.

Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

SPET imaging of central muscarinic receptors with (R,R)[I-123]-I-QNB: Methodological considerations

Author(s): R. Norbury, M. Travis, K. Erlandsson, W. Waddington, J. Owens, P. J. Ell, D. G. Murphy

Investigations on the effect of normal healthy ageing on the muscarinic system have shown conflicting results. Also, in vivo determination of muscarinic receptor binding has been hampered by a lack of subtype selective ligands and differences in methods used for quantification of receptor densities. Recent in vitro and in vivo work with the muscarinic antagonist (R,R)-1-QNB indicates this ligand has selectivity for m(1) and m(4) muscarinic receptor subtypes. Therefore, we used (R,R)[I-123]-1-QNB and single photon emission tomography to study brain m(1) and m(4) muscarinic receptors in 25 healthy female subjects (11 younger subjects, age range 26-32 years and 14 older subjects, age range 57-82 years). Our aims were to ascertain the viability of tracer administration and imaging within the same day, and to evaluate whether normalization to whole brain, compared to normalization to cerebellum, could alter the clinical interpretation of results. Images were analyzed using the simplified reference tissue model and by two ratio methods: normalization to whole brain and normalization to cerebellum. Significant correlations were observed between kinetic analysis and normalization to cerebellum, but not to whole brain. Both the kinetic analysis and normalization to cerebellum showed age-related reductions in muscarinic binding in frontal, orbitofrontal, and parietal regions. Normalization to whole brain, however, failed to detect age-related changes in any region. Here we show that, for this radiotracer, normalizing to a region of negligible specific binding (cerebellum) significantly improves sensitivity when compared to global normalization. (C) 2004 Elsevier Inc. All rights reserved.

Full version: Available here

Click the link to go to an external website with the full version of the paper

ISBN: 0969-8051
Publication Year: 2004
Periodical: Nuclear Medicine and Biology
Periodical Number: 5
Volume: 31
Pages: 583-590
Author Address: