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eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

SSRI Antidepressants Do Not Confound Single Photon Emission Computed Tomography (SPECT) Imaging Studies Using the alpha 4 beta 2 Nicotinic Acetylcholine Receptor [I-123]5-I-A85380 Ligand: In Vivo and In Vitro Evidence

Author(s): J. Cavanagh, J. Patterson, S. Pimlott, D. Wyper, D. Dewar

Abstract:
Purpose: In clinical molecular imaging the interaction between antidepressant medication and SPECT ligands is a significant potential confound. This study measured nAChR availability, as determined by SPECT imaging, on and off selective serotonin reuptake inhibitors in first episode depressed patients. Methods: Five patients in their first episode of major depressive disorder (MDD) on a single SSRI underwent [I-123]5-I-A85380- SPECT neuroimaging prior to stopping their medication and again 6 weeks following medication cessation. Autoradiography of post mortem brain tissue with [I-125]5-I-A85380 in the presence or absence of flour commonly prescribed antidepressants was also assessed. Results: SSRI antidepressants did not affect the relative binding availability of alpha 4 beta 2 nicotinic acetylcholine receptors for the [I-123]5-I-A85380 ligand in vivo. Radioligand binding in vitro was unaffected by a single, high pharmacological concentration of antidepressants. Conclusion: SPECT imaging studies using [I-123]5-I-A85380 to measure alpha 4 beta 2 nAChR availability in depressed patients are unlikely to be confounded to a major degree by concurrent antidepressant medication. Synapse 64:111-116, 2010. (C) 2009 Wiley-Liss, Inc.

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 0887-4476
Publication Year: 2009
Periodical: Synapse
Periodical Number: 2
Volume: 64
Pages: 111-116
Author Address: