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eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Stereospecific benzylic dehydroxyfluorination reactions using Bio's TMS-amine additive approach with challenging substrates

Author(s): S. Bresciani, D. O'Hagan

Abstract:
Reactions involving the conversion of a benzylic alcohol into a benzylic fluoride using RSF3 reagents are notoriously difficult to achieve with high stereochemical inversion (S(N)2 reaction) due 70 competing dissociative S(N)1 reaction processes. This Letter develops the methodology of Bio et al., and reports that the addition of a preformed 1:TMS-amine 1:RSF3 (fluorination reagent) complex as the reagent in these reactions significantly suppresses the S(N)1 process and promotes a highly stereospecific reaction generating benzylic fluorination products of high %ee. (C) 2010 Elsevier Ltd. All rights reserved.

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 0040-4039
Publication Year: 2010
Periodical: Tetrahedron Letters
Periodical Number: 44
Volume: 51
Pages: 5795-5797
Author Address: