RiiSE20 Conference Apr 04, 2020 08:30 AM - 05:00 PM — Chancellor’s Building, Edinburgh BioQuarter
Scottish Clinical Imaging Network (SCIN) Annual Event 2020 Apr 30, 2020 09:00 AM - 04:00 PM — Glasgow Caledonian University
NCITA National Conference: Translating Imaging Biomarkers for Improved Patient Outcomes May 05, 2020 10:00 AM - 05:00 PM — New Hunt's House, Guy's Campus, King's College London
Scottish Radiological Society Spring Meeting 2020 May 15, 2020 09:00 AM - 04:10 PM — Centre for Health Science, Inverness
2020 SINAPSE ASM Jun 18, 2020 - Jun 19, 2020 — Medical Sciences Building, University of St Andrews

eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Structural abnormalities of ventrolateral and orbitofrontal cortex in patients with familial bipolar disorder

Author(s): A. C. Stanfield, T. W. Moorhead, D. E. Job, J. McKirdy, J. E. Sussmann, J. Hall, S. Giles, E. C. Johnstone, S. M. Lawrie, A. M. McIntosh

Abstract:
OBJECTIVES: Abnormalities of ventral prefrontal function have been widely reported in bipolar disorder, but reports of structural abnormalities in the same region are less consistent. We examined the presence and location of ventral prefrontal abnormalities in a large sample of individuals with bipolar disorder and their relationship to gender, psychotic symptoms, and age. METHODS: Structural magnetic resonance imaging brain scans were carried out on 66 individuals with bipolar disorder, type I, and 66 controls. Voxel-based morphometry was used to examine differences in grey and white matter density between the groups and their relationship with a lifetime occurrence of psychotic symptoms and age. RESULTS: Reductions in grey matter density were seen in the left and right lateral orbital gyri and the right inferior frontal gyrus, while white matter density reductions were seen in the corona radiata and the left temporal stem. In contrast, hallucinations and positive symptoms were associated with grey matter reduction in the left middle temporal gyrus. Age was more strongly associated with the right inferior frontal gyrus grey matter reductions in the bipolar group than in the controls, but not with any other finding. CONCLUSION: Abnormalities of the ventral prefrontal cortex are likely to be involved in the aetiopathology of bipolar disorder, while hallucinations appear to be more closely associated with temporal lobe abnormality, extending earlier work in schizophrenia. Further prospective studies are required to comprehensively address the trajectory of these findings.

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 1399-5618 (Electronic) 1398-5647 (Linking)
Publication Year: 2009
Periodical: Bipolar Disord
Periodical Number: 2
Volume: 11
Pages: 135-44
Author Address: Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK. andrew.stanfield@ed.ac.uk