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eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study

Author(s): J. Burns, D. Job, M. E. Bastin, H. Whalley, T. MacGillivray, E. C. Johnstone, S. M. Lawrie

Abstract:
Background There is growing evidence that schizophrenia is a disorder of cortical connectivity Specifically, frontotemporal and frontoparietal connections are thought to be functionally impaired. Diffusion tensor magnetic resonance imaging (DT-MRI) is a technique that has the potential to demonstrate structural disconnectivity in schizophrenia. Aims To investigate the structural integrity of frontotemporal and frontoparietal white matter tracts in schizophrenia. Method Thirty patients with DSM-IV schizophrenia and thirty matched control subjects underwent DT-MRI and structural MRI. Fractional anisotropy an index of the integrity of white matter tracts - was determined in the uncinate fasciculus, the anterior cingulum and the arcuate fasciculus and analysed using voxel-based morphometry. Results There was reduced fractional anisotropy in the left uncinate fasciculus and left arcuate fasciculus in patients with schizophrenia compared with controls. Conclusions The findings of reduced white matter tract integrity in the left uncinate fasciculus and left arcuate fasciculus suggest that there is frontotemporal and frontoparietal structural disconnectivity in schizophrenia. Declaration of interest The study was supported by a grant from the Stanley Medical Research Institute.

Full version: Available here

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ISBN: 0007-1250
Publication Year: 2003
Periodical: British Journal of Psychiatry
Periodical Number:
Volume: 182
Pages: 439-443
Author Address: