Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2 '-deoxyadenosine substrates
Author(s):
S. L. Cobb, H. Deng, A. R. McEwan, J. H. Naismith, D. O'Hagan, D. A. Robinson
Abstract:
The fluorinase enzyme from Streptomyces cattleya displays an unusual ability in biocatalysis in that it forms a C - F bond. We now report that the enzyme will accept 2'-deoxyadenosine in place of adenosine substrates, and structural evidence reveals a reorganisation in hydrogen bonding to accommodate this substrate series. It emerges from this study that the enzyme does not require a planar ribose conformation of the substrate to catalyse C - F bond formation.
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ISBN:
1477-0520
Publication Year:
2006
Periodical:
Organic & Biomolecular Chemistry
Periodical Number:
8
Volume:
4
Pages:
1458-1460
Author Address:
