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eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Synthesis and binding characteristics of N-(1-naphthyl)-N '-(3-[I-125]-iodophenyl)-N '-methylguanidine ([I-125]-CNS 1261): A potential SPECT agent for imaging NMDA receptor activation

Author(s): J. Owens, A. A. Tebbutt, A. L. McGregor, K. Kodama, S. S. Magar, M. E. Perlman, D. J. Robins, G. J. Durant, J. McCulloch

Abstract:
N-(2 Naphthyl)-N'-(3-[I-125]-iodophenyl)-N'-methylguanidine ([I-125]-CNS 1261) was syn thesized as a potential radioligand to image N-methyl-D-aspartate (NMDA) receptor activation. [I-125]-CNS 1261 was prepared by radioiodination of N-(1 naphthyl)-N'-(3-tributylstannyphenyl)-N'-methylguanidine using (NaI)-I-125 and peracetic acid. [I-125]-CNS 1261 uptake in vivo reflected NMDA receptor distribution in normal rat brain, whereas in ischemic rat brain, uptake was markedly increased in areas of NMDA receptor activation. Radiolabeled CNS 1261 appears to be a good candidate for further development as a single photon emission computed tomography tracer in the investigation of NMDA receptor activation in cerebral ischemia. NUCL MED BIOL 27;6:557-564, 2000. (C) 2000 Elsevier Science Inc. All rights reserved.

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 0969-8051
Publication Year: 2000
Periodical: Nuclear Medicine and Biology
Periodical Number: 6
Volume: 27
Pages: 557-564
Author Address: