UK PET Chemistry Workshop on Radiotracer Dispensing Oct 21, 2022 09:00 AM - 05:00 PM — KCL, London
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eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists. **Unfortunately these do not currently work in browsers**


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Synthesis of fluorinated analogues of the neurosteroid GABA(A) receptor antagonist, 17-PA

Author(s): G. Deniau, K. T. Sillar, D. O'Hagan

Abstract:
The steroid 17-PA is a GABA(A) receptor antagonist which is finding use as a tool in evaluating agonistic/antagonistic activity at GABA(A) receptors. Compounds with improved efficacy over 17-PA would be are advantageous for such studies. Accordingly a series of novel analogues of the neurosteroid 17-PA have been prepared and a convenient two-step route is presented which is amenable to the synthesis of analogues with electron-donating para-aromatic substituents including fluorine. However, for the metafluoro analogue then the original four-step route to 17-PA remains more efficient overall. The paper describes these syntheses and discusses the electronic factors which influence this synthetic chemistry. (c) 2008 Elsevier B.V. All rights reserved.

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 0022-1139
Publication Year: 2008
Periodical: Journal of Fluorine Chemistry
Periodical Number: 9
Volume: 129
Pages: 881-887
Author Address: