Scottish Radiological Society Spring Meeting 2021 May 14, 2021 09:00 AM - 05:00 PM — Virtual Meeting (online)
9th Annual Scottish Radiotherapy Research Forum Jun 03, 2021 12:30 PM - 05:00 PM — Virtual Meeting (online)
Medical Imaging Convention [rescheduled] Sep 15, 2021 - Sep 16, 2021 — National Exhibition Centre, Birmingham, England
Total Body PET 2021 conference [rescheduled] Sep 25, 2021 - Sep 27, 2021 — McEwan Hall, University of Edinburgh

eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Synthesis of fluorinated analogues of the neurosteroid GABA(A) receptor antagonist, 17-PA

Author(s): G. Deniau, K. T. Sillar, D. O'Hagan

Abstract:
The steroid 17-PA is a GABA(A) receptor antagonist which is finding use as a tool in evaluating agonistic/antagonistic activity at GABA(A) receptors. Compounds with improved efficacy over 17-PA would be are advantageous for such studies. Accordingly a series of novel analogues of the neurosteroid 17-PA have been prepared and a convenient two-step route is presented which is amenable to the synthesis of analogues with electron-donating para-aromatic substituents including fluorine. However, for the metafluoro analogue then the original four-step route to 17-PA remains more efficient overall. The paper describes these syntheses and discusses the electronic factors which influence this synthetic chemistry. (c) 2008 Elsevier B.V. All rights reserved.

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 0022-1139
Publication Year: 2008
Periodical: Journal of Fluorine Chemistry
Periodical Number: 9
Volume: 129
Pages: 881-887
Author Address: