9th SINAPSE Neuro-oncology Imaging Meeting [rescheduled] Mar 11, 2021 09:30 AM - 03:30 PM — West Park Conferencing & Events, 319 Perth Road, Dundee DD2 1NN
Total Body PET 2020 conference [rescheduled] Jun 05, 2021 - Jun 07, 2021 — McEwan Hall, University of Edinburgh
Medical Imaging Convention [rescheduled] Sep 15, 2021 - Sep 16, 2021 — National Exhibition Centre, Birmingham, England

eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma

Author(s): R. Rampling, G. Cruickshank, V. Papanastassiou, J. Nicoll, D. Hadley, D. Brennan, R. Petty, A. MacLean, J. Harland, E. McKie, R. Mabbs, M. Brown

Abstract:
The herpes simplex virus (HSV) ICP34.5 null mutant 1716 replicates selectively in actively dividing cells and has been proposed as a potential treatment for cancer, particularly brain tumours. We present a clinical study to evaluate the safety of 1716 in patients with relapsed malignant glioma. Following intratumoural inoculation of doses up to 10(5) p.f.u., there was no induction of encephalitis, no adverse clinical symptoms, and no reactivation of latent HSV. Of nine patients treated, four are currently alive and well 14-24 months after 1716 administration. This study demonstrates the feasibility of using replication-competent HSV in human therapy.

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 0969-7128
Publication Year: 2000
Periodical: Gene Therapy
Periodical Number: 10
Volume: 7
Pages: 859-866
Author Address: