PET/MR User's Meeting: Technical challenges Feb 05, 2020 10:30 AM - 03:00 PM — Henry Wellcome Auditorium, 183 Euston Road, London
Launch event for Aberdeen Hub of One HealthTech Feb 13, 2020 06:00 PM - 09:00 PM — ONE Tech Hub, Schoolhill, Aberdeen
Scottish Ophthalmic Imaging Society meeting Feb 14, 2020 09:30 AM - 05:00 PM — Royal Society of Edinburgh, 22-26 George Street, Edinburgh
Scottish+ Radiotherapy Physics Meeting 2020 Feb 21, 2020 09:30 AM - 05:00 PM — Scottish Health Service Centre , Western General Hospital, Edinburgh
2nd Scottish Ultrasound Annual Scientific Meeting Feb 28, 2020 10:00 AM - 05:00 PM — Collins Building, University of Strathclyde


SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.

Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Use of dynamic contrast-enhanced MRI to measure subtle blood-brain barrier abnormalities

Author(s): P. A. Armitage, A. J. Farrall, T. K. Carpenter, F. N. Doubal, J. M. Wardlaw

There is growing interest in investigating the role of subtle changes in blood-brain barrier (BBB) function in common neurological disorders and the possible use of imaging techniques to assess these abnormalities. Some studies have used dynamic contrast-enhanced MR imaging (DCE-MRI) and these have demonstrated much smaller signal changes than obtained from more traditional applications of the technique, such as in intracranial tumors and multiple sclerosis. In this work, preliminary results are presented from a DCE-MRI study of patients with mild stroke classified according to the extent of visible underlying white matter abnormalities. These data are used to estimate typical signal enhancement profiles in different tissue types and by degrees of white matter abnormality. The effect of scanner noise, drift and different intrinsic tissue properties on signal enhancement data is also investigated and the likely implications for interpreting the enhancement profiles are discussed. No significant differences in average signal enhancement or contrast agent concentration were observed between patients with different degrees of white matter abnormality, although there was a trend towards greater signal enhancement with more abnormal white matter. Furthermore, the results suggest that many of the factors considered introduce uncertainty of a similar magnitude to expected effect sizes, making it unclear whether differences in signal enhancement are truly reflective of an underlying BBB abnormality or due to an unrelated effect. As the ultimate aim is to achieve a reliable quantification of BBB function in subtle disorders, this study highlights the factors which may influence signal enhancement and suggests that further work is required to address the challenging problems of quantifying contrast agent concentration in healthy and diseased living human tissue and of establishing a suitable model to enable quantification of relevant physiological parameters. Meanwhile, it is essential that future studies use an appropriate control group to minimize these influences. (C) 2011 Elsevier Inc. All rights reserved.

Full version: Available here

Click the link to go to an external website with the full version of the paper

ISBN: 0730-725X
Publication Year: 2011
Periodical: Magnetic Resonance Imaging
Periodical Number: 3
Volume: 29
Pages: 305-314
Author Address: